Evidence map›Paper›PMID 41993361›Full record

ArticlebioRxiv : the preprint server for biology2026

Large-scale endoplasmic reticulum membrane solidification spatially organises proteins under thermal or metabolic stress.

Paul M Müller, Melissa R Mikolaj, Elmehdi Belbaraka, Finn Hartstein, Sophia Altinoluk, Björn Perder, Philipp Trnka, Robert-William Welke, Heike Naumann, Nina Taudien and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Paul M MüllerInstitute of Chemistry and Biochemistry, Freie Universität Berlin; 14195 Berlin, Germany.
Melissa R MikolajCCR Volume Electron Microscopy (CVEM), Center for Cancer Research, National Cancer Institute, NIH; Maryland, USA.
Elmehdi BelbarakaMax-Delbrück-Center for Molecular Medicine; 13125 Berlin, Germany.
Finn HartsteinInstitute of Biochemistry, Charité Universitätsmedizin; 10117 Berlin, Germany.
Sophia AltinolukInstitute of Biochemistry, Charité Universitätsmedizin; 10117 Berlin, Germany.
Björn PerderMax-Delbrück-Center for Molecular Medicine; 13125 Berlin, Germany.
Philipp TrnkaMax-Delbrück-Center for Molecular Medicine; 13125 Berlin, Germany.
Robert-William WelkeMax-Delbrück-Center for Molecular Medicine; 13125 Berlin, Germany.
Heike NaumannMax-Delbrück-Center for Molecular Medicine; 13125 Berlin, Germany.
Nina TaudienInstitute of Biochemistry, Charité Universitätsmedizin; 10117 Berlin, Germany.
Severine KunzMax-Delbrück-Center for Molecular Medicine; 13125 Berlin, Germany.
Michele SolimenaMolecular Diabetology, University Hospital and Faculty of Medicine Carl Gustav Carus, TU Dresden; 01307 Dresden, Germany.ORCID 0000-0002-3653-8107
Ilya LeventalCenter for Membrane and Cell Physiology, University of Virginia; Charlottesville, Virginia, USA.ORCID 0000-0002-1206-9545
Kandice R LeventalCenter for Membrane and Cell Physiology, University of Virginia; Charlottesville, Virginia, USA.
Andreas MüllerMolecular Diabetology, University Hospital and Faculty of Medicine Carl Gustav Carus, TU Dresden; 01307 Dresden, Germany.ORCID 0000-0002-3560-5769
Helge EwersInstitute of Chemistry and Biochemistry, Freie Universität Berlin; 14195 Berlin, Germany.ORCID 0000-0003-3948-4332
Kedar NarayanCCR Volume Electron Microscopy (CVEM), Center for Cancer Research, National Cancer Institute, NIH; Maryland, USA.
Oliver RocksMax-Delbrück-Center for Molecular Medicine; 13125 Berlin, Germany.ORCID 0000-0001-6349-9193

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organelle homeostasis is a key determinant of cellular fitness, yet how cells remodel their membranes in response to environmental change remains unclear. Here, we identify a temperature- and lipid saturation-dependent transformation of endoplasmic reticulum membranes into giant, rigid, multilamellar tubes in cells and

Identifiers

PMID41993361
PMCPMC13081923

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.