Evidence map›Paper›PMID 41993344›Full record

ArticlebioRxiv : the preprint server for biology2026

Regulator-derived growth and fitness costs of

Madison Spratt, Cece Stumpf, Mia Vigil, Karen Snyder, Keara Lane

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Madison SprattInterdisciplinary Biological Sciences Graduate Program, Northwestern University, Evanston, Illinois, 60208, USA.ORCID 0000-0002-7925-6484
Cece StumpfDepartment of Molecular Biosciences, Northwestern University, Evanston, Illinois, 60208, USA.
Mia VigilDepartment of Molecular Biosciences, Northwestern University, Evanston, Illinois, 60208, USA.
Karen SnyderInterdisciplinary Biological Sciences Graduate Program, Northwestern University, Evanston, Illinois, 60208, USA.
Keara LaneDepartment of Molecular Biosciences, Northwestern University, Evanston, Illinois, 60208, USA.ORCID 0000-0002-8737-0455

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
CELLULAR &MOLECULAR BASIS OF DISEASE TRAINING PROGRAMT32GM008061 · NIGMS · NORTHWESTERN UNIVERSITY · PI CARTHEW, RICHARD W. · 1985 to 2022
$17.1M
NCI NIH HHS P30 CA060553NIGMS NIH HHS T32 GM008061
6 · The paper itself

Abstract

Bacterial pathogens must evolve regulatory mechanisms that balance the necessity of virulence genes with the costs associated with their expression.

Identifiers

PMID41993344
PMCPMC13082014

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.