In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
7 authors.
Dustin E TillmanDepartment of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-7450-0927 Omer DurakDepartment of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University, Cambridge, MA, USA.ORCID 0000-0001-8426-6188 Priya VeeraraghavanDepartment of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University, Cambridge, MA, USA.
John E FrobergDepartment of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University, Cambridge, MA, USA.ORCID 0000-0003-3391-7619 Garrett WheelerDepartment of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University, Cambridge, MA, USA.ORCID 0009-0005-4445-5132 Bogdan BudnikWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.ORCID 0000-0003-3622-2003 Jeffrey D MacklisDepartment of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University, Cambridge, MA, USA.ORCID 0000-0003-3662-9698 Funding
Training in the Molecular Biology of Neurodegeneration and Alzheimer's DiseaseT32AG000222 · NIA · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Bruce A YANKNER · 1992 to 2026
$18.5MTraining in Pharmacological SciencesT32GM007306 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI GOLAN, DAVID E. · 1985 to 2018
$6.6MSubcellular RNA-Proteome Mapping in Subtype- and Circuit-Specific Growth Cones: Development, Cell Biology, Disease, and RegenerationDP1NS106665 · NINDS · HARVARD UNIVERSITY · PI MACKLIS, JEFFREY D · 2017 to 2021
$5.9MMolecular Controls over Neurogenesis, Subtype Development, and Diversity of Cortical Output Projection NeuronsR01NS045523 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MACKLIS, JEFFREY D · 2002 to 2020
$5.4MSubcellular mechanisms of subtype-specific neuron vulnerability in ALS and FTD: dysregulation of synapse-localized RNA, protein, and translation in mouse models and human cortico-spinal assembloidsRF1AG083085 · NIA · HARVARD UNIVERSITY · PI MACKLIS, JEFFREY D · 2023 to 2023
$2.0MMolecular Development and Diversity of Callosal Projection NeuronsR01NS104055 · NINDS · HARVARD UNIVERSITY · PI MACKLIS, JEFFREY D · 2020 to 2024
$1.9MSynthetic System for Neuron Subtype- and Context-Specific Subcellular RNA/Protein Manipulation and Bioactive DeliveryR21NS141110 · NINDS · HARVARD UNIVERSITY · PI MACKLIS, JEFFREY D · 2024 to 2024
$481kNovel BEAM and R26-BEACON recombinase-based systems for mosaic analysis of gene functionR21NS104733 · NINDS · HARVARD UNIVERSITY · PI MACKLIS, JEFFREY D · 2018 to 2019
$465kRegulation of cortical circuit formation by subcellular compartmentalization of mRNA translationF32AG067661 · NIA · HARVARD UNIVERSITY · PI FROBERG, JOHN · 2021 to 2022
$140kSubcellular Proteomic Investigation of Projection Neuron Growth Cones in Developing Mouse CortexF31NS127518 · NINDS · HARVARD UNIVERSITY · PI TILLMAN, DUSTIN ELIOT · 2023 to 2024
$71kNIA NIH HHS F32 AG067661NIA NIH HHS RF1 AG083085NIA NIH HHS T32 AG000222NIGMS NIH HHS T32 GM007306NINDS NIH HHS DP1 NS106665NINDS NIH HHS F31 NS127518NINDS NIH HHS R01 NS045523NINDS NIH HHS R01 NS104055NINDS NIH HHS R21 NS104733NINDS NIH HHS R21 NS141110
6 · The paper itselfAbstract
Precise establishment of distinct cerebral cortex circuits is essential for sensorimotor function, high-level cognition, and cross-modality integration and association. Although an increasing set of molecular controls over subtype-specific cortical wiring have been identified, much less is known about how molecules in growth cones (GCs) regulate precise long-range projection of axons through complex environments, or how dysregulation of GC molecular machinery disrupts precision of circuit formation. Here, we discover a generalizable mechanism for regulation of precise circuit wiring by focusing on callosal projection neurons (CPN), which link cortical hemispheres via the corpus callosum. CPN are centrally involved in associative and cognitive function, and are often disrupted in people with autism spectrum disorders (ASD) and intellectual disabilities (ID). We identify dysregulated subcellular CPN GC proteomes
Identifiers
PMID41993341
PMCPMC13082108
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