ArticlebioRxiv : the preprint server for biology2026
Genetic interaction between
Valeria Aceves, Ziyi Xu, Cheng-Hai Zhang, Jongkil Kim, Joshua Ito, Kylie Mathers, Andrew B Lassar, Zhaoyang Liu, Ryan S Gray
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors.
Valeria AcevesDepartment of Nutritional Sciences, Dell Pediatric Research Institute, The University of Texas at Austin, Austin, TX 78723, United States.
Ziyi XuDepartment of Nutritional Sciences, Dell Pediatric Research Institute, The University of Texas at Austin, Austin, TX 78723, United States.
Cheng-Hai ZhangDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute at Harvard Medical School, Boston, MA 02115.
Jongkil KimDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute at Harvard Medical School, Boston, MA 02115.
Joshua ItoDepartment of Nutritional Sciences, Dell Pediatric Research Institute, The University of Texas at Austin, Austin, TX 78723, United States.
Kylie MathersDepartment of Nutritional Sciences, Dell Pediatric Research Institute, The University of Texas at Austin, Austin, TX 78723, United States.
Andrew B LassarDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute at Harvard Medical School, Boston, MA 02115.
Zhaoyang LiuCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, United States.ORCID 0000-0002-8032-1167 Ryan S GrayDepartment of Nutritional Sciences, Dell Pediatric Research Institute, The University of Texas at Austin, Austin, TX 78723, United States.ORCID 0000-0001-9668-6497 Funding
Towards a Mechanistic Undestanding of Adolscent Idiopathic ScoliosisR01AR072009 · NIAMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Ryan Scott Gray · 2017 to 2026
$3.9MThe Role of Creb5 in Maintaining Synovial Joint HomeostasisR01AR076562 · NIAMS · HARVARD MEDICAL SCHOOL · PI Andrew Bruce Lassar · 2022 to 2026
$3.4MElucidation of the Role of Creb5 in Synovial Joint FormationR01AR074385 · NIAMS · HARVARD MEDICAL SCHOOL · PI LASSAR, ANDREW BRUCE · 2019 to 2024
$3.4MMolecular Regulatory Mechanism of a Cartilage-Enriched GPCR in Joint MaintenanceR01AR083966 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Zhaoyang Liu · 2025 to 2026
$832kAnalyzing the role of cAMP and STAT3 signaling in cartilage homeostasis and osteoarthritis developmentR00AR077090 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LIU, ZHAOYANG · 2023 to 2025
$686kElucidation of the role of Creb5 in promoting the formation and patterning of the intervertebral discR21AR081990 · NIAMS · HARVARD MEDICAL SCHOOL · PI ZHANG, CHENGHAI · 2023 to 2024
$403kNIAMS NIH HHS R00 AR077090NIAMS NIH HHS R01 AR072009NIAMS NIH HHS R01 AR074385NIAMS NIH HHS R01 AR076562NIAMS NIH HHS R01 AR083966NIAMS NIH HHS R21 AR081990
6 · The paper itselfAbstract
Adolescent idiopathic scoliosis (AIS) is the most common spinal disorder in children and is best understood as a complex polygenic condition. Genome-wide association studies (GWAS) have identified several AIS risk loci, including regions near
Identifiers
PMID41993334
PMCPMC13082079
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