Evidence map›Paper›PMID 41993324›Full record

ArticlebioRxiv : the preprint server for biology2026

A conserved peptidase governs glucose homeostasis in

Kamalesh Verma, Seth G Kabonick, Kailyn M Winokur, John M Flanagan, Eduardo A Groisman, Guy E Townsend

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kamalesh VermaDepartment of Molecular and Precision Medicine, Penn State College of Medicine, Hershey, PA, USA.ORCID 0000-0002-2230-3817
Seth G KabonickDepartment of Molecular and Precision Medicine, Penn State College of Medicine, Hershey, PA, USA.ORCID 0000-0003-4539-232X
Kailyn M WinokurDepartment of Molecular and Precision Medicine, Penn State College of Medicine, Hershey, PA, USA.ORCID 0009-0001-4961-0649
John M FlanaganDepartment of Molecular and Precision Medicine, Penn State College of Medicine, Hershey, PA, USA.ORCID 0000-0002-1007-659X
Eduardo A GroismanYale University School of Medicine, Yale University, New Haven, CT, USA.ORCID 0000-0001-6860-7691
Guy E TownsendDepartment of Molecular and Precision Medicine, Penn State College of Medicine, Hershey, PA, USA.ORCID 0000-0002-8231-3769

Funding

Control of gut colonization by the prominent gut bacterium Bacteroides thetaiotaomicronR01GM123798 · NIGMS · YALE UNIVERSITY · PI GROISMAN, EDUARDO · 2018 to 2025
$2.7M
Elucidating the consequences of dietary sugar consumption on the gut microbiotaR01DK132711 · NIDDK · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI Guy Edmund Townsend · 2023 to 2026
$2.2M
Harnessing the gut microbiome to detect and quantify glycansR01GM147178 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI TOWNSEND, GUY EDMUND · 2022 to 2025
$1.8M
How Bacteroides species coordinate glycogen metabolism and global gene expression to colonize the mammalian intestineF31DK145176 · NIDDK · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI Seth G Kabonick · 2025 to 2026
$74k
NIDDK NIH HHS F31 DK145176NIDDK NIH HHS R01 DK132711NIGMS NIH HHS R01 GM123798NIGMS NIH HHS R01 GM147178
6 · The paper itself

Abstract

Glucose homeostasis is governed by peptidases across the kingdom of life. Host overconsumption of glucose transforms gut microbial compositions and activities. Here, we identify an IDE-like M16 peptidase in human gut commensal

Identifiers

PMID41993324
PMCPMC13081976

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.