Evidence map›Paper›PMID 41993308›Full record

ArticlebioRxiv : the preprint server for biology2026

Dysregulation of Hippo Signaling Pathway as a Convergent Mechanism Underlying Choroid Plexus Defects in Bipolar Disorder.

Jonghun Kim, Mu Seog Choe, Kutlu Kaya, Yue Hu, Kenneth K Ng, Caihong Qiu, Mei Zhong, Woo Sub Yang, Ferdi Ridvan Kiral, Cynthia Lo and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jonghun KimDepartment of Genetics, Yale School of Medicine, New Haven, CT, USA.
Mu Seog ChoeDepartment of Genetics, Yale School of Medicine, New Haven, CT, USA.
Kutlu KayaDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Yue HuDepartment of Biostatistics, Yale University School of Public Health, New Haven, CT, USA.
Kenneth K NgDepartment of Genetics, Yale School of Medicine, New Haven, CT, USA.
Caihong QiuYale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA.
Mei ZhongYale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA.
Woo Sub YangDepartment of Genetics, Yale School of Medicine, New Haven, CT, USA.
Ferdi Ridvan KiralDepartment of Genetics, Yale School of Medicine, New Haven, CT, USA.
Cynthia LoDepartment of Genetics, Yale School of Medicine, New Haven, CT, USA.
Michael ScanduraDepartment of Genetics, Yale School of Medicine, New Haven, CT, USA.
Hyuk-Jin ChaCollege of Pharmacy, Seoul National University, Seoul, Republic of Korea.
Jeffrey R GruenDepartment of Genetics, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-7640-2071
Monkol LekDepartment of Genetics, Yale School of Medicine, New Haven, CT, USA.
Elizabeth A JonasInterdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT, USA.
Hilary P BlumbergInterdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT, USA.
In-Hyun ParkDepartment of Genetics, Yale School of Medicine, New Haven, CT, USA.

Funding

Construction of the integrated human forebrain organoids to investigate neurodevelopmental disordersR01MH118344 · NIMH · YALE UNIVERSITY · PI In-Hyun Park · 2019 to 2026
$4.0M
High Performance Computing Instrumentation for the Yale Center for Genome AnalysisS10OD030363 · OD · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2022 to 2022
$1.2M
6500 QTrap Mass Spectrometer for Yale UniversityS10OD018034 · OD · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2014 to 2014
$514k
An Ultra-Performance Liquid Chromatography System to Support Metabolomics at Yale UniversityS10OD019967 · OD · YALE UNIVERSITY · PI LAM, TUKIET T · 2015 to 2015
$135k
NIH HHS S10 OD018034NIH HHS S10 OD019967NIH HHS S10 OD030363NIMH NIH HHS R01 MH118344
6 · The paper itself

Abstract

Bipolar disorder (BD) is a prevalent and highly heritable psychiatric condition. Developmental mechanisms are implicated but the specific molecular origins remain unclear. The choroid plexus (ChP), which regulates cerebrospinal fluid (CSF) and brain homeostasis, has been implicated in BD, but its role is poorly understood. Here, we identify aberrant expansion of ChP in human cortical (hCOs) and ChP organoids (hChPOs) derived from, and

Identifiers

PMID41993308
PMCPMC13081963

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.