Evidence map›Paper›PMID 41993305›Full record

ArticlebioRxiv : the preprint server for biology2026

Comparative analysis of varicella-zoster virus and herpes simplex virus 1 interaction with epidermal terminal differentiation in primary human keratinocytes models of differentiation.

Cristina Tommasi, Geonhee Kim, Aoxin Liu, Andriani Drousioti, Olumide Ogunbiyi, Oscar Enrique Torres Montaguth, Afshin Mosahebi, Judith Breuer

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cristina TommasiInfection, Immunity and Inflammation Department, University College London GOS Institute of Child Health, London, UK.ORCID 0000-0002-4314-5088
Geonhee KimInfection, Immunity and Inflammation Department, University College London GOS Institute of Child Health, London, UK.
Aoxin LiuInfection, Immunity and Inflammation Department, University College London GOS Institute of Child Health, London, UK.
Andriani DrousiotiInfection, Immunity and Inflammation Department, University College London GOS Institute of Child Health, London, UK.
Olumide OgunbiyiHistopathology Department, Camelia Botnar Laboratories, University College London Great Ormond Street Hospital for Children, London, UK.
Oscar Enrique Torres MontaguthInfection, Immunity and Inflammation Department, University College London GOS Institute of Child Health, London, UK.ORCID 0000-0003-4234-6037
Afshin MosahebiDepartment of Surgical Biotechnology, Royal Free Hospital, University College London, London, UK.
Judith BreuerInfection, Immunity and Inflammation Department, University College London GOS Institute of Child Health, London, UK.ORCID 0000-0001-8246-0534

Funding

VZV vaccine attenuation and the DNA damage responseR01AI158510 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Paul R. Kinchington · 2022 to 2026
$3.2M
NIAID NIH HHS R01 AI158510
6 · The paper itself

Abstract

Varicella-zoster virus (VZV) is the etiological agent of chickenpox and herpes zoster, while herpes simplex virus 1 (HSV-1) causes oral and genital herpes. Both infections manifest with skin blisters from which the viruses are transmitted to new hosts either via aerosol (VZV) or skin microabrasions (HSV-1). VZV reaches the skin through the blood route, and in the skin epidermis it first infects undifferentiated keratinocytes of the basal layer. Conflicting evidence exists for HSV-1, making it unclear whether HSV-1 infects undifferentiated or differentiated keratinocytes. Here, we developed

Identifiers

PMID41993305
PMCPMC13082075

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.