Evidence map›Paper›PMID 41993300›Full record

ArticlebioRxiv : the preprint server for biology2026

Mechanism of GPR84 allosteric modulation at a helix 8-proximate site.

Xuan Zhang, Abdul-Akim Guseinov, Laura Jenkins, Jingkai Zhou, Fabian Gossen, Pinqi Wang, Zobaer Al Mahmud, Yueming Li, Andhika B Mahardhika, Christa E Müller and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Xuan ZhangDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, U.S.A.
Abdul-Akim GuseinovSchool of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, U.K.
Laura JenkinsSchool of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, U.K.
Jingkai ZhouDepartment of Immuno-Oncology, Beckman Research Institute, City of Hope, Duarte, CA, 91010, USA.
Fabian GossenUniversity of Bonn, PharmaCenter Bonn & Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, An der Immenburg 4, 53121 Bonn, Germany.
Pinqi WangDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.
Zobaer Al MahmudSchool of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, U.K.
Yueming LiSchool of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, U.K.
Andhika B MahardhikaUniversity of Bonn, PharmaCenter Bonn & Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, An der Immenburg 4, 53121 Bonn, Germany.
Christa E MüllerUniversity of Bonn, PharmaCenter Bonn & Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, An der Immenburg 4, 53121 Bonn, Germany.
Mingye FengDepartment of Immuno-Oncology, Beckman Research Institute, City of Hope, Duarte, CA, 91010, USA.
Angela J RussellDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.ORCID 0000-0003-3610-9369
Irina G TikhonovaSchool of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, Northern Ireland, U.K.
Graeme MilliganSchool of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, U.K.
Cheng ZhangDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, U.S.A.

Funding

Structure, pharmacology and signaling of G protein-coupled receptors (GPCRs) in inflammationR35GM128641 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHENG ZHANG · 2018 to 2026
$3.5M
Cryo-electron microscopeS10OD025009 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CONWAY, JAMES F. · 2018 to 2018
$2.0M
Direct electron detecting (DED) cameraS10OD019995 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CONWAY, JAMES F. · 2015 to 2015
$548k
NIGMS NIH HHS R35 GM128641NIH HHS S10 OD019995NIH HHS S10 OD025009
6 · The paper itself

Abstract

Allosteric modulators offer opportunities for pathway-selective GPCR signalling, but the structural mechanisms enabling biased allosteric modulation remain unclear. Here we identify a helix 8-proximate allosteric site in the immune-metabolic receptor GPR84 and define how it achieves G

Identifiers

PMID41993300
PMCPMC13082019

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.