Evidence map›Paper›PMID 41993297›Full record

ArticlebioRxiv : the preprint server for biology2026

Neuroanatomical and behavioral characterization of corticotropin releasing factor-expressing lateral Habenula neurons in mice.

William J Flerlage, Shawn C Gouty, Emily H Thomas, Sarah C Simmons, Mumeko C Tsuda, Oana L Rujan, Regina C Armstrong, Catherine M Davis, Laxmi Iyer, Emily Petrus and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

William J FlerlageUniformed Services University of the Health Sciences, Department of Pharmacology and Molecular Therapeutics, Bethesda, MD 20814, USA.
Shawn C GoutyUniformed Services University of the Health Sciences, Department of Pharmacology and Molecular Therapeutics, Bethesda, MD 20814, USA.
Emily H ThomasUniformed Services University of the Health Sciences, Department of Pharmacology and Molecular Therapeutics, Bethesda, MD 20814, USA.
Sarah C SimmonsUniformed Services University of the Health Sciences, Department of Pharmacology and Molecular Therapeutics, Bethesda, MD 20814, USA.
Mumeko C TsudaUniformed Services University of the Health Sciences, Preclinical Behavior and Modeling Core, Bethesda, MD 20814, USA.
Oana L RujanUniformed Services University of the Health Sciences, Department of Pharmacology and Molecular Therapeutics, Bethesda, MD 20814, USA.
Regina C ArmstrongUniformed Services University of the Health Sciences, Department of Anatomy, Physiology, and Genetics, Bethesda, MD 20814, USA.
Catherine M DavisUniformed Services University of the Health Sciences, Department of Pharmacology and Molecular Therapeutics, Bethesda, MD 20814, USA.ORCID 0000-0002-2591-6352
Laxmi IyerHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Emily PetrusUniformed Services University of the Health Sciences, Department of Anatomy, Physiology, and Genetics, Bethesda, MD 20814, USA.
Brian M CoxUniformed Services University of the Health Sciences, Department of Pharmacology and Molecular Therapeutics, Bethesda, MD 20814, USA.
T John WuUniformed Services University of the Health Sciences, Department of Gynecologic Surgery and Obstetrics, Bethesda, MD 20814, USA.
Fereshteh S NugentUniformed Services University of the Health Sciences, Department of Pharmacology and Molecular Therapeutics, Bethesda, MD 20814, USA.ORCID 0000-0002-8840-6923

Funding

Intrinsic CRF signaling within the lateral habenulaR21MH132136 · NIMH · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI NUGENT, FERESHTEH S · 2023 to 2024
$418k
NIMH NIH HHS R21 MH132136
6 · The paper itself

Abstract

The lateral habenula (LHb) is a critical hub for stress-related behaviors, yet the sources of its corticotropin-releasing factor (CRF) inputs remain poorly defined. Using high-resolution imaging, RNAscope, and viral tracing, we identified a novel, intrinsic population of CRF-expressing LHb neurons (LHb

Identifiers

PMID41993297
PMCPMC13081983

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.