Evidence map›Paper›PMID 41993289›Full record

ArticlebioRxiv : the preprint server for biology2026

A Non-Classical Neuroactive Steroid Exhibiting Potent, Efficacious GABA

Hong-Jin Shu, Yuanjian Xu, Mingxing Qian, Ann Benz, Carla M Yuede, Douglas F Covey, Charles F Zorumski, Steven Mennerick

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hong-Jin ShuDepartment of Psychiatry, Washington University in St. Louis School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110.
Yuanjian XuDepartment of Developmental Biology, Washington University in St. Louis School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110.
Mingxing QianDepartment of Developmental Biology, Washington University in St. Louis School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110.
Ann BenzDepartment of Psychiatry, Washington University in St. Louis School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110.
Carla M YuedeDepartment of Psychiatry, Washington University in St. Louis School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110.ORCID 0000-0001-6362-4767
Douglas F CoveyDepartment of Psychiatry, Washington University in St. Louis School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110.ORCID 0000-0002-9316-8683
Charles F ZorumskiDepartment of Psychiatry, Washington University in St. Louis School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110.ORCID 0000-0002-9704-5154
Steven MennerickDepartment of Psychiatry, Washington University in St. Louis School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110.ORCID 0000-0003-0868-0664

Funding

Neuroactive steroids as novel psychiatric treatments: mechanistic studiesP50MH122379 · NIMH · WASHINGTON UNIVERSITY · PI EVERS, ALEX S. · 2021 to 2025
$12.2M
GABAA RECEPTOR POPULATIONS IN HIPPOCAMPUS AND THALAMUSR01MH123748 · NIMH · WASHINGTON UNIVERSITY · PI MENNERICK, STEVEN J · 2021 to 2025
$2.4M
NIMH NIH HHS P50 MH122379NIMH NIH HHS R01 MH123748
6 · The paper itself

Abstract

Neuroactive steroids modulate GABA

Identifiers

PMID41993289
PMCPMC13081942

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.