ArticlebioRxiv : the preprint server for biology2026
Early Epigenetic and Metabolic Responses to the Adipocyte Secretome Reveal Stress-Adaptive States in Triple-Negative Breast Cancer.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Obesity is a well-established risk factor for triple-negative breast cancer (TNBC), yet how adipocyte-derived signals reprogram cancer cell metabolism and chromatin states remains poorly defined. Here, we investigate how adipocyte-driven lipogenesis reshapes metabolic-epigenetic coupling to support stress-adaptive cell states and functional changes in epithelial TNBC cells. Using an integrated multi-omic approach, we combine RNA sequencing (RNA-seq), chromatin accessibility (ATAC-seq), metabolic flux modeling, and functional metabolic assays in lipogenic BT-549 cells. Computational modeling trained on RNA-seq predicts shifts in metabolic pathway usage, including enhanced NAD-linked metabolism. RNA-seq reveals a predominance of gene activation, consistent with ATAC-seq data showing a strong bias toward increased accessibility. Regions of increased accessibility are enriched for stress-adaptive and antioxidant pathways, including superoxide dismutase 2 (
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