Evidence map›Paper›PMID 41993279›Full record

ArticlebioRxiv : the preprint server for biology2026

Structural and biochemical characterization of a novel inhibitor of NMNAT1, the gatekeeper of nuclear NAD

Carisse Lansiquot, Ruoxi Wu, Joanna P Davies, Xiangyang Song, H Ümit Kaniskan, Jian Jin, Michael B Lazarus

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Carisse LansiquotDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029.ORCID 0000-0003-1118-7299
Ruoxi WuDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029.ORCID 0000-0002-3136-3280
Joanna P DaviesDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Xiangyang SongDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029.ORCID 0009-0000-0136-3899
H Ümit KaniskanDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029.ORCID 0000-0001-5327-832X
Jian JinDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Michael B LazarusDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029.ORCID 0000-0002-6738-2563

Funding

NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9M
Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
NCCAT: National Center for CryoEM Access and TrainingR24GM154192 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI EDWARD T ENG, Jeffrey S Kieft · 2024 to 2026
$21.0M
ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
Chemical and structural tools to study energy homeostasis pathways in cancer and diabetesR35GM124838 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Michael Block Lazarus · 2017 to 2026
$5.2M
NCATS NIH HHS UL1 TR004419NIGMS NIH HHS R01 GM129325NIGMS NIH HHS R24 GM154192NIGMS NIH HHS R35 GM124838NIGMS NIH HHS U24 GM129539
6 · The paper itself

Abstract

Nicotinamide adenine dinucleotide (NAD

Identifiers

PMID41993279
PMCPMC13082068

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.