Evidence map›Paper›PMID 41993266›Full record

ArticlebioRxiv : the preprint server for biology2026

Gain-of-function mutation in

Courtney M Tamaki, Chester E Chamberlain, Clare L Abram, Sumith Poojary, Jennifer Bridge, Jennifer L Matsuda, Whitney Tamaki, Niklas Rutsch, Lauren Spector, Wesley Dixon and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Courtney M TamakiDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143. U.S.A.
Chester E ChamberlainDiabetes Center, University of California San Francisco, San Francisco, CA 94143. U.S.A.ORCID 0009-0007-7648-8531
Clare L AbramDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143. U.S.A.
Sumith PoojaryDiabetes Center, University of California San Francisco, San Francisco, CA 94143. U.S.A.
Jennifer BridgeDiabetes Center, University of California San Francisco, San Francisco, CA 94143. U.S.A.
Jennifer L MatsudaGenetically Engineered Murine Models (GEMM) Core, Dept of Immunology and Microbiology, University of Colorado-Anschutz.
Whitney TamakiDepartment of Medicine, University of California San Francisco, San Francisco, CA 94143. U.S.A.
Niklas RutschDepartment of Anesthesiology, Intensive Care, and Pain Medicine, University Hospital Münster, University of Münster, 48149 Münster, Germany.
Lauren SpectorDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143. U.S.A.
Wesley DixonDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143. U.S.A.
Irina ProektDiabetes Center, University of California San Francisco, San Francisco, CA 94143. U.S.A.
Lisa R Letourneau-FreibergSection of Adult and Pediatric Endocrinology, Diabetes, and Metabolism and the Kovler Diabetes Center, The University of Chicago, Chicago, IL. U.S.A.
Louis H PhilipsonSection of Adult and Pediatric Endocrinology, Diabetes, and Metabolism and the Kovler Diabetes Center, The University of Chicago, Chicago, IL. U.S.A.
Michael S GermanDiabetes Center, University of California San Francisco, San Francisco, CA 94143. U.S.A.
Mark S AndersonDiabetes Center, University of California San Francisco, San Francisco, CA 94143. U.S.A.
Clifford A LowellDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143. U.S.A.

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8M
Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI RONALD N COHEN · 2013 to 2026
$20.9M
DIABETES, ENDOCRINOLOGY &METABOLISM TRAINING PROGRAMT32DK007418 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDWARD C HSIAO · 1986 to 2026
$14.3M
Monogenic Diabetes: Next Generation Diagnosis, Treatment and ComplicationsR01DK104942 · NIDDK · UNIVERSITY OF CHICAGO · PI GREELEY, SIRI ATMA W., PHILIPSON, LOUIS H. · 2016 to 2024
$4.7M
Alterations of leukocyte integrin signaling leading to diabetes and autoimmunityR01AI170841 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S, GERMAN, MICHAEL S · 2022 to 2025
$2.6M
A shared resource for multiplexed ion beam imaging microscopyS10OD025187 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VANDENBERG, SCOTT RUSSEL · 2018 to 2018
$1.2M
Wide-field super-resolution spinning disk confocal microscopeS10OD028611 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WITTMANN, TORSTEN · 2020 to 2020
$600k
BD FACSAria Fusion Cell SorterS10OD021822 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, MICHAEL R. · 2016 to 2016
$573k
NIAID NIH HHS R01 AI170841NIDDK NIH HHS P30 DK020595NIDDK NIH HHS P30 DK063720NIDDK NIH HHS R01 DK104942NIDDK NIH HHS T32 DK007418NIH HHS S10 OD021822NIH HHS S10 OD025187NIH HHS S10 OD028611
6 · The paper itself

Abstract

Many genetic variants associated with increased type 1 diabetes (T1D) risk are located within the

Identifiers

PMID41993266
PMCPMC13081829

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.