Evidence map›Paper›PMID 41993259›Full record

ArticlebioRxiv : the preprint server for biology2026

Energy-precision trade-off in mitotic oscillators revealed by ATP modulation in artificial cells.

Shiyuan Wang, Liam Yourston, Gembu Maryu, Yeonghoon Kim, Derek Walker, Usha Kadiyala, Qiong Yang

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shiyuan WangDepartment of Biophysics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Liam YourstonDepartment of Biophysics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Gembu MaryuDepartment of Biophysics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Yeonghoon KimDepartment of Biophysics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Derek WalkerDepartment of Physics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Usha KadiyalaDepartment of Biophysics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Qiong YangDepartment of Biophysics, University of Michigan, Ann Arbor, Michigan 48109, USA.ORCID 0000-0002-2442-2094

Funding

Understanding the robustness of cell cyclesR01GM144584 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Qiong Yang · 2023 to 2026
$1.2M
NIGMS NIH HHS R01 GM144584
6 · The paper itself

Abstract

The temporal precision of biochemical oscillators is fundamentally constrained by the energy dissipated to suppress molecular fluctuations, a widely predicted trade-off governing information processing across biology and physics, from molecular motors to kinetic proofreading to computing. Yet, experimental validation in complex biological oscillators remains elusive due to challenges of systematically modulating energy while quantifying stochastic dynamics across large ensembles. Here, we establish a high-throughput droplet-microfluidics platform to reconstitute mitotic oscillations from

Identifiers

PMID41993259
PMCPMC13082052

What OpenQuestion holds

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LicenceCC BY-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.