Evidence map›Paper›PMID 41993180›Full record

ArticleFrontiers in immunology2026

Enhancement of host anti-mycobacterial immunity by green tea hot-water extract is mediated through miR-9-5p-enriched lung extracellular vesicles.

Jiayu Zhou, Liying Zhu, Yalin Wang, Yuan Wu, Min Yang, Wei Xu, Xiaosai Ma, Chonghai Qiu, Xiaoran Bian, Fangying Yi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jiayu Zhou *Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infections Disease and Biosecurity, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Liying Zhu *Shanghai Clinical Research Center for Infectious Disease (Tuberculosis), Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Institute for Advanced Study, Tongji University School of Medicine, Shanghai, China.
Yalin Wang *Institute of Science and Technology, Fudan University, Shanghai, China.
Yuan WuKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infections Disease and Biosecurity, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Min YangKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infections Disease and Biosecurity, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Wei XuState Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, China.
Xiaosai MaKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infections Disease and Biosecurity, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Chonghai QiuKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infections Disease and Biosecurity, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Xiaoran BianKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infections Disease and Biosecurity, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Fangying YiKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infections Disease and Biosecurity, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Hongbo ShenShanghai Clinical Research Center for Infectious Disease (Tuberculosis), Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Institute for Advanced Study, Tongji University School of Medicine, Shanghai, China.
Feifei WangKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infections Disease and Biosecurity, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Green tea, rich in bioactive compounds, is widely recognized for its immunomodulatory and anti-infection potential. In this study, we systematically evaluated the efficacy of green tea hot-water extract (GHWE) in modulating host antimycobacterial immunity. We first demonstrated that GHWE treatment enhanced the capacity of human peripheral blood mononuclear cells (PBMCs) to inhibit intracellular mycobacterial growth. This protective effect was further validated

Indexed as

Extracellular VesiclesLungMicroRNAsPlant ExtractsTeaAnimalsBronchoalveolar Lavage FluidFemaleHumansLeukocytes, MononuclearMiceMice, Inbred C57BLMycobacterium bovisMicroRNAsMIRN9 microRNA, mousePlant ExtractsTeaextracellular vesiclesgreen tea hot-water extractgut-lung axismiR-9-5pMycobacteria tuberculosis

Identifiers

PMID41993180
PMCPMC13079060

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.