Evidence map›Paper›PMID 41993147›Full record

ArticleAutophagy reports2026

Autophagy selectively clears ER in TNF-α-induced muscle atrophy.

Ursula K Dueren, Alan An Jung Wei, A Elisabeth Gressler, Simon Rapp, Oliver Popp, Robert Kerridge, Viviana Buonomo, Paolo Grumati, Philipp Mertins, Matthias Selbach and 2 more

Abstract read
In one paragraph

Article in Autophagy reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ursula K DuerenMax Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.ORCID https://orcid.org/0009-0006-4407-9031
Alan An Jung WeiMax Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.ORCID https://orcid.org/0000-0003-4255-9470
A Elisabeth GresslerMax Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.ORCID https://orcid.org/0000-0003-3229-1554
Simon RappMax Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.ORCID https://orcid.org/0000-0002-5141-0611
Oliver PoppMax Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.ORCID https://orcid.org/0000-0001-6240-4666
Robert KerridgeMax Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Viviana BuonomoTelethon Institute of Genetics and Medicine, Pozzuoli, Italy.
Paolo GrumatiTelethon Institute of Genetics and Medicine, Pozzuoli, Italy.ORCID https://orcid.org/0000-0002-9942-9389
Philipp MertinsProteomics Platform, Max Delbrück Center for Molecular Medicine, Berlin, Germany.ORCID https://orcid.org/0000-0002-2245-528X
Matthias SelbachMax Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.ORCID https://orcid.org/0000-0003-2454-8751
Anna Katharina SimonMax Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.ORCID https://orcid.org/0000-0002-4077-7995
Thomas SommerInstitute for Biology, Humboldt-University zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0001-9990-5202

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skeletal muscle atrophy is a pathological condition characterized by the progressive loss of muscle mass and function, driven by factors such as disuse, inflammation, and aging. While the ubiquitin-proteasome system is established as the central mediator of myofibrillar protein degradation, the role of selective autophagy and the degradation of organelles remains underexplored in this context. To address this, we employed a quantitative, time-resolved

Indexed as

autophagyDynamic SILACER-phagyinflammationmuscle atrophyproteostasisTNF-α

Identifiers

PMID41993147
PMCPMC13081748

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.