ArticleImaging neuroscience (Cambridge, Mass.)
An fMRI examination of the role of the Locus Coeruleus in state regulation in ADHD.
Article in Imaging neuroscience (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The state regulation deficit account of attention-deficit hyperactivity disorder (ADHD) posits that symptoms and performance deficits associated with ADHD are context-dependent and explained by a deficit in arousal regulation. Research into this topic has often used event rate manipulations to induce different arousal states, and has demonstrated deficits at both overstimulating and understimulating event rate levels. Although existing research has provided strong support for the state regulation deficit account, little is known about the neurobiological substrate of state regulation deficits. An important candidate brain network is the Locus Coeruleus-noradrenergic (LC-NE) system, which has been hypothesized by several researchers to play a key role in state regulation deficits in ADHD. In the current study, we examined, for the first time, the role of the LC in state regulation deficits in ADHD using high-resolution fMRI scans. We presented a target detection task at three event rate levels (fast, moderate, slow) to adults with (
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