Evidence map›Paper›PMID 41993134›Full record

ArticleHuman mutation2026

Gang Wang, Zilu Guo, Jing Ren, Ge Zhang, Hanlin Tao, Yihan Liu, Siming Zheng, Xuan Zhang, Di Wang, Rumeng Zhao and 5 more

Abstract read
In one paragraph

Article in Human mutation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Human mutation · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Gang WangHenan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, China, hnsrmyy.net.ORCID https://orcid.org/0009-0001-6974-9971
Zilu GuoHenan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, China, hnsrmyy.net.ORCID https://orcid.org/0009-0008-7215-0397
Jing RenHenan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, China, hnsrmyy.net.ORCID https://orcid.org/0000-0001-7993-1104
Ge ZhangDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China, zzu.edu.cn.ORCID https://orcid.org/0000-0002-3116-3246
Hanlin TaoHenan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, China, hnsrmyy.net.ORCID https://orcid.org/0009-0001-7169-7226
Yihan LiuHenan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, China, hnsrmyy.net.ORCID https://orcid.org/0009-0006-5056-2660
Siming ZhengDepartment of Hematology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China, zzu.edu.cn.ORCID https://orcid.org/0009-0003-7231-2070
Xuan ZhangHenan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, China, hnsrmyy.net.ORCID https://orcid.org/0009-0008-1570-7929
Di WangHenan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, China, hnsrmyy.net.ORCID https://orcid.org/0000-0001-5949-4269
Rumeng ZhaoHenan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, China, hnsrmyy.net.ORCID https://orcid.org/0009-0001-2068-8629
Huiling CuiHenan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, China, hnsrmyy.net.ORCID https://orcid.org/0009-0003-9218-1442
Shichao ZhuDepartment of Pharmacy, Chongqing General Hospital, Chongqing University, Chongqing, China, cqu.edu.cn.ORCID https://orcid.org/0000-0003-3408-2676
Hongen XuAcademy of Medical Science, Tianjian Laboratory of Advanced Biomedical Sciences, Zhengzhou University, Zhengzhou, China, zzu.edu.cn.ORCID https://orcid.org/0000-0001-7895-0899
Shichao DuanHenan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, China, hnsrmyy.net.ORCID https://orcid.org/0000-0002-3177-4194
Haijun LiHenan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, China, hnsrmyy.net.ORCID https://orcid.org/0009-0004-4717-2966

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Approximately 60% of glaucoma patients have a family history. Family-based studies indicate that relatives of glaucoma patients have a 10-fold higher risk of developing glaucoma compared to the control population. Genetic mutations have been reported as potential contributing factors to pathogenesis of glaucoma. In this study, we reported a Chinese family that many members affected with primary open-angle glaucoma carried a

Indexed as

Genetic Predisposition to DiseaseGlaucoma, Open-AngleHeterozygoteMutationPregnancy-Associated Plasma Protein-AAnimalsEast Asian PeopleFemaleGenetic Association StudiesHumansInsulin-Like Growth Factor Binding Protein 5MaleMiceMiddle AgedPedigreeTrabecular MeshworkIGFBP5 protein, humanInsulin-Like Growth Factor Binding Protein 5Pregnancy-Associated Plasma Protein-AfibrosisglaucomaIGFBP5PAPPA2trabecular meshwork

Identifiers

PMID41993134
PMCPMC13080692

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.