Evidence map›Paper›PMID 41993090›Full record

ArticleEuropean heart journal open2026

MyD88 in myeloid cells drives angiotensin II-induced vascular inflammation, is associated with prevalent heart failure, and predicts all-cause mortality in arterial hypertension.

Sabine Wild, Stefanie Finger, Andreas Schulz, Melania Aluia, Jimena Bravo, Rahul Kumar, Jeremy Lagrange, Gregorio Alanis-Lobato, Voahanginirina Randriamboavonjy, Johannes Wild and 16 more

Abstract read
In one paragraph

Article in European heart journal open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Sabine WildCenter for Cardiology, University Medical Center Mainz, Langenbeckstrasse 1, Mainz 55131, Germany.
Stefanie FingerCenter for Cardiology, University Medical Center Mainz, Langenbeckstrasse 1, Mainz 55131, Germany.
Andreas SchulzPreventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center Mainz, Langenbeckstrasse 1, Mainz 55131, Germany.
Melania AluiaCenter for Thrombosis and Hemostasis Mainz, University Medical Center Mainz, Langenbeckstrasse 1, Mainz 55131, Germany.
Jimena BravoInstitute of Transfusion-Medicine Center, University Medical Center Mainz, Langenbeckstrasse 1, Mainz 55131, Germany.
Rahul KumarInstitute of Transfusion-Medicine Center, University Medical Center Mainz, Langenbeckstrasse 1, Mainz 55131, Germany.
Jeremy LagrangeCenter for Thrombosis and Hemostasis Mainz, University Medical Center Mainz, Langenbeckstrasse 1, Mainz 55131, Germany.
Gregorio Alanis-LobatoFaculty of Biology, Johannes Gutenberg University Mainz, Gresemundweg 2, Mainz 55128, Germany.
Voahanginirina RandriamboavonjyGerman Center for Cardiovascular Research (DZHK)-Partner Site Rhine-Main, Germany.ORCID https://orcid.org/0000-0002-3542-6672
Johannes WildCenter for Cardiology, University Medical Center Mainz, Langenbeckstrasse 1, Mainz 55131, Germany.ORCID https://orcid.org/0000-0002-1446-8101
Michael MolitorCenter for Cardiology, University Medical Center Mainz, Langenbeckstrasse 1, Mainz 55131, Germany.
Christian MüllerInstitute for Cardiogenetics, University Hospital Schleswig Holstein, University of Luebeck, Ratzeburger Allee 160, Lübeck 23562  Germany.
Tanja ZellerInstitute for Cardiogenetics, University Hospital Schleswig Holstein, University of Luebeck, Ratzeburger Allee 160, Lübeck 23562  Germany.ORCID https://orcid.org/0000-0003-3379-2641
Alexander GieswinkelGerman Center for Cardiovascular Research (DZHK)-Partner Site Rhine-Main, Germany.
Andreas DaiberCenter for Cardiology, University Medical Center Mainz, Langenbeckstrasse 1, Mainz 55131, Germany.ORCID https://orcid.org/0000-0002-2769-0094
Susanne Helena KarbachCenter for Cardiology, University Medical Center Mainz, Langenbeckstrasse 1, Mainz 55131, Germany.
Marcus DörrInstitute for Community Medicine, University Medicine Greifswald, Walther-Rathenau-Str. 48, 17475 Greifswald, Germany.
Ingrid FlemingGerman Center for Cardiovascular Research (DZHK)-Partner Site Rhine-Main, Germany.ORCID https://orcid.org/0000-0003-1881-3635
Philipp LurzCenter for Cardiology, University Medical Center Mainz, Langenbeckstrasse 1, Mainz 55131, Germany.
Thomas MünzelCenter for Cardiology, University Medical Center Mainz, Langenbeckstrasse 1, Mainz 55131, Germany.ORCID https://orcid.org/0000-0001-5503-4150
Markus RadsakIIIrd Medical Clinic, University Medical Center Mainz, Langenbeckstrasse 1, Mainz 55131, Germany.
Katrin SchäferCenter for Cardiology, University Medical Center Mainz, Langenbeckstrasse 1, Mainz 55131, Germany.ORCID https://orcid.org/0000-0003-0846-4718
Daniela S KrauseInstitute of Transfusion-Medicine Center, University Medical Center Mainz, Langenbeckstrasse 1, Mainz 55131, Germany.
Miguel A Andrade-NavarroFaculty of Biology, Johannes Gutenberg University Mainz, Gresemundweg 2, Mainz 55128, Germany.
Philipp WildCenter for Thrombosis and Hemostasis Mainz, University Medical Center Mainz, Langenbeckstrasse 1, Mainz 55131, Germany.
Philip WenzelCenter for Cardiology, University Medical Center Mainz, Langenbeckstrasse 1, Mainz 55131, Germany.ORCID https://orcid.org/0000-0002-5397-2781

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Angiotensin II (AngII) causes hypertension and vascular inflammation and is essential in neurohumoral activation promoting the development of heart failure. The role of the adaptor protein myeloid factor of differentiation 88 (MyD88) driving this pathology remains incompletely understood. Methods and results: Male C57BL/6JMyD88 Conclusion: MyD88 promotes AngII-induced vascular dysfunction and arterial hypertension and might serve as both an inflammatory diagnostic marker and a drug target to tackle the risk of death and incident heart failure in hypertensive patients.

Indexed as

Arterial hypertensionHeart FailureMyD88Myeloid cells

Identifiers

PMID41993090
PMCPMC13080514

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.