ArticleJournal of oral biology and craniofacial research
Fractionated ethanolic red ginger extract as antibacterial agent against
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Background: Periodontitis is a chronic inflammatory disease associated with oral microbiome dysbiosis, where Objective: To evaluate the antibacterial activity of fractionated ethanolic red ginger extract against Methods: Twenty-two bioactive compounds identified from the fractionated extract were analyzed via molecular docking against cytolethal distending toxin (Cdt) of Results: Docking analysis showed that cyclooctacosane and gamma-sitosterol demonstrated binding affinities comparable to chlorhexidine toward both target proteins. The extract exhibited MIC/MBC values of 0.062/0.125 mg/mL for Conclusion: Fractionated ethanolic red ginger extract demonstrates promising antibacterial activity against key periodontal pathogens by targeting virulence mechanisms related to adhesion and biofilm formation, supporting its potential as a natural adjunct in periodontal therapy.
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