Evidence map›Paper›PMID 41992981›Full record

ReviewInternational journal of molecular medicine2026

ETS‑1/ETS‑2 transcription factors in CVD (Review).

Shasha Yang, Jing Zhang, Ying Yang, Yunbo Lv, Jian Yang, Huibo Wang

Abstract readReview
In one paragraph

Review in International journal of molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shasha Yang *Department of Cardiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei 443002, P.R. China.
Jing Zhang *Institute of Cardiovascular Diseases, China Three Gorges University, Yichang, Hubei 443002, P.R. China.
Ying YangInstitute of Cardiovascular Diseases, China Three Gorges University, Yichang, Hubei 443002, P.R. China.
Yunbo LvInstitute of Cardiovascular Diseases, China Three Gorges University, Yichang, Hubei 443002, P.R. China.
Jian YangInstitute of Cardiovascular Diseases, China Three Gorges University, Yichang, Hubei 443002, P.R. China.
Huibo WangInstitute of Cardiovascular Diseases, China Three Gorges University, Yichang, Hubei 443002, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular diseases remain the leading cause of global morbidity and mortality, imposing a significant burden on families and societies. E26 transformation‑specific (ETS)‑1 and ETS‑2, members of the ETS family of transcription factors (also known as proto‑oncogenes), are increasingly recognized for their roles in tumor progression. Recent studies highlight their importance in normal coronary artery development, myocardial homeostasis and the regulation of vascular inflammation and remodeling. Emerging evidence suggests that ETS‑1/ETS‑2 are critical in the pathogenesis of atherosclerosis, myocardial ischemia‑reperfusion injury, cardiac remodeling and heart failure. The present review summarized the research progress of ETS‑1/ETS‑2 in cardiovascular diseases, discusses the relevant challenges encountered in the translational process of ETS‑1/ETS‑2‑targeted therapy for cardiovascular diseases and provides novel strategies for the treatment of cardiovascular diseases targeting ETS‑1/ETS‑2.

Indexed as

Cardiovascular DiseasesProto-Oncogene Protein c-ets-1Proto-Oncogene Protein c-ets-2AnimalsHumansProto-Oncogene Protein c-ets-1Proto-Oncogene Protein c-ets-2atherosclerosiscardiovascular diseasesE26 transformation‑specific‑1E26 transformation-specific‑2heart failuremyocardial remodeling

Identifiers

PMID41992981
PMCPMC13105394

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.