Evidence map›Paper›PMID 41992934›Full record

ArticleAnnals of neurology2026

Multimodal Image Guidance in Subthalamic Deep Brain Stimulation for Parkinson's Disease.

Patricia Zvarova, Christina van der Linden, Ningfei Li, Konstantin Butenko, Thea Berger, Garance M Meyer, Ilkem Aysu Sahin, Lukas L Goede, Bahne H Bahners, Barbara Hollunder and 18 more

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In one paragraph

Article in Annals of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Patricia ZvarovaMovement Disorder and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0009-0004-7831-8796
Christina van der LindenDepartment of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0003-2091-4638
Ningfei LiMovement Disorder and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0003-3315-3591
Konstantin ButenkoMovement Disorder and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Thea BergerDepartment of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Garance M MeyerCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Ilkem Aysu SahinMovement Disorder and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0009-0005-9951-374X
Lukas L GoedeMovement Disorder and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Bahne H BahnersCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Barbara HollunderMovement Disorder and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Till A DembekDepartment of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0001-7023-146X
Andrew R PinesCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Martin ReichDepartment of Neurology, University Clinic of Würzburg, Würzburg, Germany.
Jens VolkmannDepartment of Neurology, University Clinic of Würzburg, Würzburg, Germany.
Vincent J J OdekerkenDepartment of Neurology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Rob M A de BieDepartment of Neurology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Xin XuDepartment of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
Zhipei LingDepartment of Neurosurgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China.
Chen YaoDepartment of Neurosurgery, The National Key Clinic Specialty, Shenzhen Key Laboratory of Neurosurgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Andrea A KühnMovement Disorder and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Surjo R SoekadarEinstein Center for Neurosciences Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Kerstin RitterEinstein Center for Neurosciences Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Michael T BarbeDepartment of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Veerle Visser-VandewalleDepartment of Stereotactic and Functional Neurosurgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Michael D FoxCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8848-6399
Jan Niklas Petry-SchmelzerDepartment of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0003-0749-3840
Nanditha Rajamani *Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Andreas Horn *Center for Brain Circuit Therapeutics, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Funding

BRAIN CONNECTS: The center for Large-scale Imaging of Neural Circuits (LINC)UM1NS132358 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Suzanne N Haber, Elizabeth M. C. Hillman · 2023 to 2026
$17.5M
Toward Connectomic Deep Brain Stimulation in Obsessive Compulsive DisorderR01MH130666 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2022 to 2026
$3.9M
Deutsche Forschungsgemeinschaft 502436811Einstein Center for Neurosciences BerlinEinstein Stiftung Berlin 424778381Koeln Fortune ScholarshipNIH HHS 1R01NS127892-01NIH HHS 2R01 MH113929NIH HHS R01MH130666NIH HHS UM1NS132358
6 · The paper itself

Abstract

objectiveAccurate electrode placement and individual stimulation parameters influence the outcomes of subthalamic deep brain stimulation in Parkinson's disease. Neuroimaging-based models can help evaluate how electrode placement impacts improvement, aiming to reduce the burden of programming. However, most existing models have been developed to explain differences between patients rather than differences between contacts within the same patient, leaving the clinical relevance of image-guided programming unclear.

methodsWe analyzed data from patients with Parkinson's disease treated with subthalamic deep brain stimulation to develop and validate a neuroimaging-informed model of motor improvement measured by the Unified Parkinson's Disease Scale. Five approaches were tested: active contact coordinates, electric fields, tract activations, as well as structural and functional networks. All approaches were integrated into a combined ridge regression model and validated using 2 hold-out datasets.

resultsThe sample included 236 patients (604 stimulation sites), divided into a training cohort (N = 129), a retrospective validation cohort (N = 89), and a prospectively acquired validation cohort (N = 21 electrodes). Consistent with expectations, our model explained approximately 12% of the variance in unseen group-level data (R

interpretationAn imaging-informed model explained the expected variance at the group level and demonstrated potential for guiding stimulation programming, suggesting that image-guided approaches may improve clinical decision making while reducing the need for lengthy postoperative testing. ANN NEUROL 2026;100:22-35.

Indexed as

Deep Brain StimulationMultimodal ImagingParkinson DiseaseSubthalamic NucleusAgedFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingRetrospective StudiesTreatment Outcome

Identifiers

PMID41992934
PMCPMC13327559

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.