Evidence map›Paper›PMID 41992815›Full record

SynthesisBrain and behavior2026

Efficacy Assessment of Supramarginal Resection Versus Gross Total Resection in Glioblastoma: A Systematic Literature Review and Meta-Analysis.

Dipak Chaulagain, Volodymyr Smolanka, Andriy Smolanka, Kashif Qureshi, Kivanc Yangi, Oleg Devnyak, Bipin Chaurasia

Erratum issuedAbstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Dipak ChaulagainNeurosurgery Department, Regional Clinical Center of Neurosurgery and Neurology, Uzhhorod National University, Uzhhorod, Ukraine.ORCID https://orcid.org/0000-0001-6428-8371
Volodymyr SmolankaNeurosurgery Department, Regional Clinical Center of Neurosurgery and Neurology, Uzhhorod National University, Uzhhorod, Ukraine.ORCID https://orcid.org/0000-0001-7296-8297
Andriy SmolankaNeurosurgery Department, Regional Clinical Center of Neurosurgery and Neurology, Uzhhorod National University, Uzhhorod, Ukraine.ORCID https://orcid.org/0000-0002-6582-9472
Kashif QureshiDepartment of Neurosurgery, Yale School of Medicine, New Haven, Connecticut, USA.ORCID https://orcid.org/0009-0002-7734-0567
Kivanc YangiDepartment of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona, USA.ORCID https://orcid.org/0000-0003-0500-218X
Oleg DevnyakPharmacology Department, Uzhhorod National University, Uzhhorod, Ukraine.ORCID https://orcid.org/0000-0001-5696-7614
Bipin ChaurasiaNeurosurgery Department, Neurosurgery Clinic, Birgunj, Nepal.ORCID https://orcid.org/0000-0002-8392-2072

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe standard treatment for glioblastoma multiforme (GBM) typically involves a surgical resection followed by radiation therapy and chemotherapy. The extent of resection (EOR) plays a significant role in predicting the prognosis of GBM. The literature showed improved survival outcomes with greater removal of contrast-enhancing tumor mass. We aim to compare the effects of supramarginal resection and gross total resection for the management of GBM.

methodsA systematic search was conducted from electronic databases (PubMed/Medline, Cochrane Library, and Google Scholar) from inception to February 10, 2024. All statistical analyses were conducted in Review Manager 5.4.1. Twelve studies meeting the inclusion criteria were selected. A random-effects model was used when heterogeneity was observed to pool the studies, and the results were reported as hazard ratio (HR), odds ratio (OR), and standard mean difference (SMD), along with their respective 95% confidence intervals (CI). Primary outcomes were overall survival, Karnofsky Performance Status, and age; secondary outcomes included median progression-free survival, mortality, and tumor recurrence.

resultsSupramarginal resection was associated with improved overall survival compared with gross total resection (HR = 0.90, 95% CI 0.84-0.97; p = 0.005; I

conclusionSupramarginal resection of GBM yielded more favorable results than gross total resection, with minimal difference between adverse effects.

Indexed as

Brain NeoplasmsGlioblastomaNeurosurgical ProceduresHumansNeoplasm Recurrence, LocalTreatment Outcomeglioblastoma multiformegross total resectionsupramarginal resection

Identifiers

PMID41992815
PMCPMC13087537

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.