SynthesisBrain and behavior2026
Neurofunctional Correlates of Emotional Dysregulation: Systematic Review and ALE Meta-Analysis.
Synthesis in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Neurofunctional Correlates of Emotional Dysregulation: Systematic Review and ALE Meta-Analysis.Brain and behavior · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundEmotional dysregulation (ED) is a transdiagnostic feature of several psychiatric and neurodevelopmental disorders, characterized by heightened emotional reactivity, mood instability, and difficulties regulating emotional responses.
methodsIn this study, an activation likelihood estimation (ALE) meta-analysis was conducted to examine the neural underpinnings of ED across different clinical populations. A systematic search based on preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines identified 35 task-based fMRI studies (n = 1989 subjects), including patients with borderline personality disorder (BPD), attention-deficit/hyperactivity disorder (ADHD), bipolar disorder (BD), and other conditions.
resultsHyper-activation was observed in emotion-related regions, particularly bilateral amygdala and left insula, indicating heightened emotional sensitivity and reactivity. Hypo-activation, detected through Bayesian thresholding, was found in areas such as the anterior cingulate cortex and supplementary motor area, suggesting impairments in cognitive control and emotional regulation. Functional connectivity analysis revealed distinct patterns of coactivation, with the amygdala showing isolated activity and the left insula coactivating with regions related to sensory processing and cognitive control.
conclusionsThese findings provide new insights into the neural circuitry of transdiagnostic ED and suggest that disorders, such as BPD, ADHD, and BD, share common neural mechanisms, particularly in regions involved in emotional reactivity and cognitive regulation. The results have important clinical implications for developing targeted interventions to address both emotional and cognitive deficits in ED. Future research should explore causal mechanisms and incorporate diverse clinical populations to further understand neurobiological basis of ED.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.