ReviewCancer biology & medicine2026
Poor prognosis outcome tumors, bacteria-infected tumors and nanodrugs: current evidence and hypotheses towards a paradigm change for treatment.
Review in Cancer biology & medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
New therapies and supportive care have converted several cancer types into chronic conditions. Yet, some tumors exhibit features reproducibly correlated with poor prognosis outcome (PPO-tumors). Bacteria in a tumor environment can inactivate chemotherapeutics and are a feature of PPO-tumors, although standard diagnostic tests for tumor infections do not exist. Optimism is high for nanotechnologic innovations but nanoparticulate chemotherapeutics based on enhanced permeability and retention in a human tumor environment have only shown limited treatment benefits. Moreover, treatment of infected tumors in animals with stimuli-responsive nanocarriers loaded with an antibiotic/chemotherapeutic combination has demonstrated limited benefits compared to treatment with combinations of carrier-free antibiotics and chemotherapeutics. Development of nanoparticulate chemotherapeutics with significant benefits in human clinical use is estimated to take several decades, which is too long for patients with PPO-tumors. Herein we hypothesize the following: 1-all diagnosed PPO-tumors are infected with bacteria; 2-all PPO-tumors in mice and humans exhibit enhanced permeability to chemotherapeutics; and 3-all diagnosed PPO-tumors must be treated from the onset with a combination of carrier-free antibiotics and chemotherapeutics. Each hypothesis was critically evaluated and judged plausible and clinically acceptable. Potential clinical treatment of PPO-tumors, presuming bacterial infection without diagnosis, with an approved antibiotic and chemotherapeutic free drug combination requires a paradigm change in treatment concept towards more lenient antibiotic use. However, many cancer patients already require antibiotics during chemotherapeutic treatment and combined carrier-free antibiotic/chemotherapeutic treatment may provide an immediate pathway to re-sensitize PPO-tumors to clinically used chemotherapeutics and alter the prognosis to a more favourable outcome.
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