Evidence map›Paper›PMID 41992586›Full record

ArticleCNS neuroscience & therapeutics2026

Depression Mediates the Association Between Ambient Air Pollution and Gastrointestinal/Liver Diseases: A Prospective Cohort Study.

Yanqi Kou, Shicai Ye, Mouji Liang, Lei Ge, Ling Qin, Yanping Ha, Yuan Tian, Botao Luo, Chunyi Wu, Liping Zhan and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yanqi KouDepartment of Gastroenterology, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, Guangdong, China.
Shicai YeDepartment of Gastroenterology, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, Guangdong, China.
Mouji LiangDepartment of Gastroenterology, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, Guangdong, China.
Lei GeDepartment of Gastrointestinal Surgery, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, Guangdong, China.
Ling QinDepartment of Hematology, The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, China.
Yanping HaDepartment of Gastroenterology, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, Guangdong, China.
Yuan TianDepartment of Gastroenterology, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, Guangdong, China.
Botao LuoDepartment of Gastroenterology, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, Guangdong, China.
Chunyi WuDepartment of Gastroenterology, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, Guangdong, China.
Liping ZhanDepartment of Gastroenterology, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, Guangdong, China.
Ke YangDepartment of Gastrointestinal Surgery, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, Guangdong, China.
Zhuoyan LuDepartment of Gastroenterology, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, Guangdong, China.
Yuping YangDepartment of Gastroenterology, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, Guangdong, China.ORCID https://orcid.org/0000-0001-5597-1881

Funding

In-Hospital Funding Clinical Research Project of the Affiliated Hospital of Guangdong Medical University LCYJ2023A002The Clinical Research Special Fund Project of the Guangdong Medical Association 2024QC-A2004The Guangdong Provincial Medical Science and Technology Research Fund Project B2024202
6 · The paper itself

Abstract

backgroundThe escalating burden of gastrointestinal (GI) and liver diseases poses a critical public health challenge, with emerging evidence implicating air pollution as a modifiable risk factor. However, the mechanistic pathways, particularly the mediating role of depression in the pollution-disease nexus, remain underexplored. This study investigates the longitudinal associations between ambient air pollution exposure and GI/liver diseases in a nationwide cohort, with a focus on quantifying depression's mediating effects.

methodsUtilizing data from the China Health and Retirement Longitudinal Study (CHARLS, 2011-2020; n = 18,755), we evaluated the impact of long-term exposure to PM

resultsChronic exposure to PM

conclusionsThis study pioneers the identification of depression as a mediator linking air pollution to GI/liver diseases in a nationally representative cohort. The findings advocate for integrative policies targeting air quality improvement and mental health interventions to alleviate the dual burden of environmental and psychological morbidity.

Indexed as

Air PollutionDepressionEnvironmental ExposureGastrointestinal DiseasesLiver DiseasesAgedAir PollutantsChinaCohort StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedParticulate MatterProspective StudiesAir PollutantsParticulate Matterair pollutiondepressiongastrointestinal diseasesliver diseasespublic health

Identifiers

PMID41992586
PMCPMC13087092

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.