Evidence map›Paper›PMID 41992579›Full record

ArticleJournal of medical primatology2026

Validation of Immunoassays for Total Thyroxine and Free Thyroxine and Age and Sex-Related Variation in Thyroid Hormone Serum Concentrations in Orangutans (Pongo sp.).

Melissa A Fayette, Anneke Moresco, Enass Bassiouny, Dalen W Agnew, Brian Petroff

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical primatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Melissa A FayetteIndianapolis Zoo, Indianapolis, Indiana, USA.ORCID https://orcid.org/0000-0001-7371-394X
Anneke MorescoReproductive Health Surveillance Program, Morrison, Colorado, USA.ORCID https://orcid.org/0000-0002-1525-1166
Enass BassiounyMichigan State University College of Veterinary Medicine, East Lansing, Michigan, USA.
Dalen W AgnewReproductive Health Surveillance Program, Morrison, Colorado, USA.
Brian PetroffMichigan State University College of Veterinary Medicine, East Lansing, Michigan, USA.

Funding

Indianapolis Zoological Society, Inc.Orangutan Species Survival Plan
6 · The paper itself

Abstract

backgroundThyroid disease is reported in orangutans, but to properly diagnose and manage these disorders, reference intervals for circulating thyroid hormones are needed.

methodsCommercial immunoassay kits for total thyroxine (TT

resultsFemale orangutans had significantly higher TT

conclusionsAge and sex-related variation in circulating thyroid hormone concentrations in orangutans is described. Elevated TSH levels are the most consistent finding in orangutans with clinical signs of hypothyroidism.

Indexed as

Thyroid HormonesThyroxineAge FactorsAnimalsFemaleHypothyroidismImmunoassayMaleReference ValuesSex FactorsThyrotropinTriiodothyronineThyroid HormonesThyrotropinThyroxineTriiodothyroninehypothyroidismorangutanPongo sp.thyroid stimulating hormonethyroxinetriiodothyronine

Identifiers

PMID41992579
PMCPMC13087480

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.