Evidence map›Paper›PMID 41992493›Full record

Trial reportJournal of clinical periodontology2026

Surgical Reconstructive Peri-Implantitis Treatment for 3- and 4-Wall Bone Defects: A Single-Blind Randomised Controlled Trial With a 1-Year Follow-Up.

Jarno Hakkers, Yvonne C M de Waal, Barzi Gareb, Henny J A Meijer, Gerry M Raghoebar

Abstract readRandomized Controlled TrialComparative Study
In one paragraph

Trial report in Journal of clinical periodontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jarno HakkersDepartment of Oral and Maxillofacial Surgery, University Medical Center Groningen and University of Groningen, Groningen, the Netherlands.ORCID 0000-0002-6991-7218
Yvonne C M de WaalCenter for Dentistry and Oral Hygiene, University Medical Center Groningen and University of Groningen, Groningen, the Netherlands.ORCID 0000-0001-5638-462X
Barzi GarebDepartment of Oral and Maxillofacial Surgery, University Medical Center Groningen and University of Groningen, Groningen, the Netherlands.
Henny J A MeijerDepartment of Oral and Maxillofacial Surgery, University Medical Center Groningen and University of Groningen, Groningen, the Netherlands.ORCID 0000-0003-1702-6031
Gerry M RaghoebarDepartment of Oral and Maxillofacial Surgery, University Medical Center Groningen and University of Groningen, Groningen, the Netherlands.ORCID 0000-0003-3578-7141

Funding

Department of Oral and Maxillofacial Surgery of the University Medical Center
6 · The paper itself

Abstract

aimTo evaluate the effect of a reconstructive procedure during surgical treatment of peri-implantitis in 3- or 4-wall bone defects on clinical and radiographic outcomes after 1 year follow-up. MATERIALS AND

methodsFifty-two patients with peri-implantitis were randomly assigned to surgical treatment with (n = 27) or without (n = 25) a reconstructive procedure using autologous bone, xenograft and a collagen membrane. Primary outcomes were the mean peri-implant probing depth (PPD) and radiographic marginal bone level (MBL). Bleeding on probing (BoP) was the prespecified primary outcome in the original protocol; the present report emphasises PPD and MBL outcomes relevant to reconstructive treatment. Secondary outcomes included BoP, disease resolution (composite treatment outcome), suppuration (SoP), mid-buccal recession (Midbuc REC) and keratinised mucosa (Midbuc KM). Data were analysed using multilevel mixed-effects models.

resultsMixed-effects models showed that patients in the test group showed enhanced marginal bone levels at all follow-ups (β = -0.85 to -1.65 mm; p ≤ 0.04) and less mid-buccal recession (β = -1.06 to -1.68 mm; p ≤ 0.01) compared to the control group. No significant differences were observed for PPD, BoP, SoP, Midbuc KM or disease resolution.

conclusionWhile the adjunctive reconstructive procedure did not significantly influence peri-implant PPD, BoP, SoP or disease resolution, it was associated with improved radiographic marginal bone levels and reduced mid-buccal soft-tissue recession.

Indexed as

Peri-ImplantitisPlastic Surgery ProceduresAdultAgedAlveolar Bone LossAutograftsBone TransplantationCollagenFemaleFollow-Up StudiesGingival RecessionHeterograftsHumansMaleMembranes, ArtificialMiddle AgedCollagenMembranes, Artificial

Identifiers

PMID41992493
PMCPMC13167631

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.