Evidence map›Paper›PMID 41992448›Full record

ArticleDrug delivery2026

Angiopep-2-decorated bacterial outer membrane vesicles penetrate the blood-brain barrier for glioblastoma chemo-immunotherapy.

Pir Tariq Shah, Zhangrong Lou, Xiaojing Zhu, Wenrui Jin, Chen Chen, Tao Hu, Peng Guo, Xuanzhu Zhao, Fan Li, Yin Xiaoliang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Pir Tariq ShahCore Laboratory, Qingdao Central Hospital, School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao, Shandong Province, China.
Zhangrong LouFaculty of Medicine, School of Basic Medical Sciences, Dalian University of Technology, Dalian, Liaoning Province, China.
Xiaojing ZhuShandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong province, China.
Wenrui JinShandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong province, China.
Chen ChenShandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong province, China.
Tao HuShandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong province, China.
Peng GuoShandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong province, China.
Xuanzhu ZhaoFaculty of Medicine, School of Basic Medical Sciences, Dalian University of Technology, Dalian, Liaoning Province, China.
Fan LiShandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong province, China.
Yin XiaoliangDepartment of Neurosurgery, Peking University Third Hospital, Beijing, China.
Zhenyong WuShandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong province, China.
Chengjun WuCore Laboratory, Qingdao Central Hospital, School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao, Shandong Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma (GBM) therapy remains one of the most formidable challenges in oncology because of the blood-brain barrier (BBB), immunosuppressive tumor microenvironment, and drug resistance. To overcome these challenges, we designed engineered angiopep-2-decorated bacterial outer membrane vesicles for targeted drug delivery across the BBB. Using a novel autotransporter-based (AIDA-I) genetic engineering approach, we developed a novel platform via straightforward genetic modification of

Indexed as

Bacterial Outer MembraneBlood-Brain BarrierBrain NeoplasmsDoxorubicinGlioblastomaPeptidesAnimalsCell Line, TumorDrug Delivery SystemsEscherichia coliHumansImmunotherapyMiceAngiopep-2DoxorubicinPeptidesAngiopep-2blood-brain barrierdrug carriersGlioblastomaouter membrane vesiclesreceptor-mediated transcytosis

Identifiers

PMID41992448
PMCPMC13094214

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.