Evidence map›Paper›PMID 41992337›Full record

Observational studyRadiation oncology (London, England)2026

Quantifying intrafractional colon tumor motion on 1.5 T MR-linac cine-MRI and applying anisotropic residual-motion margins for SBRT.

Guoqing Liu, Min Liu, Li Pan, Bisheng Liu, Na Huang, Yanhua Liu, Gang Niu, Shuanghong Wu, Xianliang Wang, Bo Song and 1 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Radiation oncology (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06244537 (Study on the Safety and Efficacy of MR-Linac Technique in Patients With Unresectable Locally Advanced Colon Cancer), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06244537 narecruitingnot on this map

Study on the Safety and Efficacy of MR-Linac Technique in Patients With Unresectable Locally Advanced Colon Cancer

TypeinterventionalSponsorSichuan Cancer Hospital and Research InstituteRan2024 to 2027Enrolled20ConditionsSafety and EfficacyArmsMR-linac
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Guoqing Liu *Department of Radiation Oncology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Min Liu *Department of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
Li Pan *Department of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
Bisheng LiuDepartment of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
Na HuangDepartment of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
Yanhua LiuCollege of Nuclear Technology and Automation Engineering, Chengdu University of Technology, Chengdu, China.
Gang NiuDepartment of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
Shuanghong WuDepartment of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
Xianliang WangDepartment of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
Bo SongDepartment of Colorectal Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China. bo_yuejun@163.com.
Qian PengDepartment of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China. pengqian@scszlyy.org.cn.

Funding

Sichuan Medical Association Tumor/Anaesthesia/Radiation/Chronic Disease/Neurology (Hengrui-Yixing) Special Research Project No. 2024HR11Sichuan Provincial Science and Technology Support Program No. 2026YFHZ0186Sichuan Science and Technology Program No. 2025HJRC0032
6 · The paper itself

Abstract

purposeTo noninvasively quantify the intrafraction motion of unresectable locally advanced colon cancer (UNLACC) via 1.5 T magnetic resonance imaging and linear accelerator (MR-linac) cine-MRI and assess the preliminary feasibility of translating motion envelopes into individualized, anisotropic residual-motion margins for stereotactic body radiotherapy (SBRT) workflow.

methodsThis prospective, single‑centre, observational cross‑sectional study serves as a preliminary test to validate the workflow of a phase I single-arm clinical study and falls under the preliminary feasibility verification phase (Clinical Trials.gov NCT06244537; Initial Release Time: 01/25/2024). We first performed internal validation of a rolling-ball-based motion extraction (RBME) algorithm using a dynamic phantom on the same 1.5 T MR linac, which demonstrated negligible systematic error with a Bland‒Altman mean bias of 0.01 mm (standard deviation 0.49 mm) and 95% limits of agreement of -0.98~0.95 mm. We then prospectively accrued 24 patients for a simulated MR-linac workflow and applied RBME to cine-MRI to generate patient- and axis-specific motion envelopes. Intrafraction motion was analysed in a repeated-measures framework to test axis-by-site effects. Finally, we conducted a planning simulation prescribing 25 Gy in 5 fractions; no patients yet treated according to the proposed strategy. The simulated planning target volume (PTV) is the gross tumor volume (GTV) plus an RBME-derived anisotropic residual-motion margin and an additional 3 mm setup margin.

resultsPhantom testing supported the accuracy of RBME ( ~ ± 1 mm agreement). In patients, the mean excursions peak in the caudal/right/anterior directions and are smallest in the cranial/left/posterior directions, with the average of means centered at approximately 4 ~ 5 mm. Across all lesions, mean root-mean-square (RMS) displacement was 2.64 ± 1.32 mm cranio-caudal, 2.91 ± 1.05 mm anterior-posterior, and 2.75 ± 1.43 mm left-right. The corresponding 95th percentile (P95) excursions were 4.49 ± 2.43 mm, 4.97 ± 1.74 mm, and 4.76 ± 2.62 mm. Axis-by-segment interactions were significant for RMS (χ² 19.93, df 8, P = 0.011) and P95 (χ² 20.44, df 8, P = 0.008), indicating location-dependent anisotropy.

conclusionA phantom-validated RBME algorithm was used to characterise irregular intrafraction motion for UNLACC on a 1.5T MR-linac. The resulting motion envelopes should be regarded as hypothesis-generating and intended to inform further method development and protocol design.

Indexed as

Colonic NeoplasmsMagnetic Resonance Imaging, CineRadiosurgeryRadiotherapy Planning, Computer-AssistedAlgorithmsAnisotropyCross-Sectional StudiesDose Fractionation, RadiationFemaleHumansMaleParticle AcceleratorsPhantoms, ImagingProspective StudiesMagnetic resonance imaging and linear accelerator (MR-linac)Rolling ball-based motion extraction (RBME)Stereotactic body radiotherapy (SBRT)Unresectable locally advanced colon cancer (UNLACC)

Identifiers

PMID41992337
PMCPMC13191885

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.