ArticleJournal of cardiothoracic surgery2026
Management of massive paravalvular leak (PVL): a case report of transcatheter mitral paravalvular leak closure.
Article in Journal of cardiothoracic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundParavalvular leak (PVL), a complication following either surgical or transcatheter prosthetic heart valve replacement, can lead to severe clinical consequences including refractory heart failure and persistent hemolysis. Transcatheter paravalvular leak closure (TPVLC) represents an effective therapeutic option for PVL management; however, clinical experience remains relatively limited, particularly regarding its application in cases of massive paravalvular leaks, where reported cases managed with a single occluder are notably scarce. We present a 69-year-old female with rheumatic heart disease complicated by mitral stenosis with regurgitation, severe tricuspid regurgitation, NYHA III heart failure, and persistent atrial fibrillation. Seven months prior to the current procedure, the patient underwent Bioprosthetic mitral valve replacement, tricuspid annuloplasty. During follow-up, she developed progressive exertional chest pain. Three-Dimensional Transesophageal echocardiography (3D-TEE) revealed: (1) recurrent moderate tricuspid regurgitation, and (2) severe paravalvular leak (14 × 7 mm) around the mitral prosthesis. Following comprehensive evaluation by the heart team, the patient underwent transcatheter mitral paravalvular leak closure, which was successfully completed with the implantation of a single 22 –16 mm AVPII occluder. Post-procedural 3D-TEE assessment demonstrated near-complete resolution of the paravalvular leak and a significant improvement in tricuspid regurgitation. The patient recovered well and showed marked improvement in cardiac function over nearly one year of follow-up.
conclusionThis case successfully confirms the technical feasibility of using a single occluder for TPVLC in treating such massive PVLs and provides valuable experience for the clinical management of similar cases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.