Evidence map›Paper›PMID 41992298›Full record

ArticleVeterinary research2026

Absence of a dose-response relationship after intra-oropharyngeal inoculation of pigs with foot-and-mouth disease virus serotype O.

Kira Wisnewski, Constantin Lorenz, Saskia Weber, Selma Schmidt, Ryan Waters, Phaedra Eblé, Aldo Dekker, Wilhelm Gerner, Michael Eschbaumer

Abstract readMulticenter Study
In one paragraph

Article in Veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kira WisnewskiInstitute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald, Germany.
Constantin LorenzInstitute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald, Germany.
Saskia WeberInstitute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald, Germany.
Selma SchmidtThe Pirbright Institute, Pirbright, Woking, UK.
Ryan WatersThe Pirbright Institute, Pirbright, Woking, UK.
Phaedra EbléWageningen Bioveterinary Research (Part of Wageningen University & Research), Lelystad, the Netherlands.
Aldo DekkerWageningen Bioveterinary Research (Part of Wageningen University & Research), Lelystad, the Netherlands.
Wilhelm GernerThe Pirbright Institute, Pirbright, Woking, UK.
Michael EschbaumerInstitute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald, Germany. Michael.Eschbaumer@fli.de.

Funding

Biotechnology and Biological Sciences Research Council BBS/E/PI/230001B , BBS/E/PI/230001CBiotechnology and Biological Sciences Research Council BBS/E/PI/23NB0004, BBS/E/PI/23NB0003HORIZON EUROPE Framework Programme 101059924Ministry of Agriculture, Fisheries, Food Security and Nature of the Netherlands WOT-01-002-034
6 · The paper itself

Abstract

Foot-and-mouth disease virus (FMDV) poses significant economic threats to livestock industries worldwide, with its serotype O being the most prevalent globally and responsible for all outbreaks in Europe in the last 25 years. This retrospective multi-centre study evaluated the dose-response relationship after intra-oropharyngeal (IOP) inoculation of pigs with FMDV O, combining independently obtained results from three research institutes. Four virus isolates were evaluated: a recombinant O/FRA/2001 virus containing the P1-coding region of O/BUL/2011, O/TAW/97, O/UKG/34/2001, and O/Manisa/TUR/69, at doses up to 8 × 10^6 TCID

Indexed as

Foot-and-Mouth DiseaseFoot-and-Mouth Disease VirusSwine DiseasesAnimalsOropharynxRetrospective StudiesSerogroupSus scrofaSwineanimal challengeanimal modelsFMDVFoot-and-mouth diseaseinoculationintra-oropharyngealmulti-laboratory studypathogenesispigsvirus

Identifiers

PMID41992298
PMCPMC13088693

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.