Evidence map›Paper›PMID 41992290›Full record

ArticleStem cell research & therapy2026

From collapse to comeback: Luteolin rejuvenates nucleus pulposus progenitor cells via SIRT1/ATF5-UPRmt to reverse intervertebral disc degeneration cascade.

Huofeng Wu, Shuangjia Zai, Xuan You, Chen Liu, Zhaoyu Li, Zhengguang Li, Yuhui Mei, Benkui Hua, Yuping Tao, Yiming Wu and 1 more

Abstract read
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In one paragraph

Article in Stem cell research & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Huofeng Wu *Department of Orthopedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, Jiangsu, China.
Shuangjia Zai *Department of Orthopedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, Jiangsu, China.
Xuan YouDepartment of Orthopedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, Jiangsu, China.
Chen LiuDepartment of Orthopedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, Jiangsu, China.
Zhaoyu LiDepartment of Orthopedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, Jiangsu, China.
Zhengguang LiDepartment of Orthopedics, The Yangzhou Clinical Medical College of Xuzhou Medical University, Yangzhou, 225001, Jiangsu, China.
Yuhui MeiDepartment of Orthopedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, Jiangsu, China.
Benkui HuaDepartment of Orthopedics, The Yangzhou Clinical Medical College of Xuzhou Medical University, Yangzhou, 225001, Jiangsu, China.
Yuping TaoDepartment of Orthopedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, Jiangsu, China.
Yiming WuDepartment of Pharmacy, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, Jiangsu, China. 17374769@qq.com.
Liang ZhangDepartment of Orthopedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, Jiangsu, China. zhangliang6320@sina.com.

Funding

Key Projects of Social Development of Yangzhou City YZ2021083/YZ2022091National Natural Science Foundation of China 82172462Postgraduate Research and Practice Innovation Program of Jiangsu Province SJCX24_2340Technology Project of Northern Jiangsu People's Hospital FCJS202504the Sixth "333 Project" Outstanding Young Talent Scientific Research Project of Jiangsu Province 11
6 · The paper itself

Abstract

backgroundIntervertebral disc degeneration (IVDD) is a major contributor to low back pain (LBP) and one of the foremost causes of disability worldwide. Oxidative stress-induced senescence of nucleus pulposus progenitor cells (NPPC) and mitochondrial dysfunction are key drivers of IVDD. The mitochondrial unfolded protein response (UPR

methodsWe employed an integrated approach combining network pharmacology, molecular docking, and Mendelian randomization to identify and validate SIRT1 as a central target of Lut in IVDD. Human nucleus pulposus (NP) tissues spanning Pfirrmann grades II-V were analyzed to assess the expression of SIRT1 and UPR

resultsHuman NP specimens exhibited a progressive decline in SIRT1, ATF5, and UPR

conclusionThis study establishes SIRT1 as a central therapeutic target of Lut and underscores the SIRT1-ATF5-UPR

Indexed as

Activating Transcription FactorsIntervertebral Disc DegenerationLuteolinNucleus PulposusSirtuin 1Stem CellsUnfolded Protein ResponseAnimalsFemaleHumansMaleMitochondriaRatsRats, Sprague-DawleyActivating Transcription FactorsATF5 protein, humanLuteolinSIRT1 protein, humanSirtuin 1Intervertebral disc degenerationMendelian randomizationMitochondrial unfolded protein responseMolecular dynamicsNetwork pharmacology

Identifiers

PMID41992290
PMCPMC13202852

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.