Evidence map›Paper›PMID 41992173›Full record

ArticleBMC palliative care2026

Identifying palliative care needs in children with acute lymphoblastic leukemia: validation of the Chinese paediatric palliative screening scale (C-PaPaS).

Alidannu Nueraili, Junye Jiang, Hongsheng Wang, Xiaohua Zhu, Yi Yu, Ping Cao, Yang Fu, Jun Li, Ling Yu, Lei Cheng and 1 more

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Article in BMC palliative care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Alidannu Nueraili *Department of Hematology and Oncology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Junye Jiang *Department of Hematology and Oncology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Hongsheng Wang *Department of Hematology and Oncology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Xiaohua ZhuDepartment of Hematology and Oncology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Yi YuDepartment of Hematology and Oncology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Ping CaoDepartment of Hematology and Oncology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Yang FuDepartment of Hematology and Oncology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Jun LiDepartment of Hematology and Oncology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Ling YuDepartment of Hematology and Oncology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Lei ChengSchool of Medicine, Fudan University, Shanghai, China. chengleis@126.com.
Xiaowen ZhaiDepartment of Hematology and Oncology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China. xwzhai@fudan.edu.cn.

Funding

China Medical Board Open Competition Grant #21-427National Key Research and Development Program of China No. 2023YFC2706301National Natural Science Foundation of China 82141125Science and Technology Commission of Shanghai Municipality 21Y31900302
6 · The paper itself

Abstract

backgroundTimely identification of pediatric palliative care (PPC) needs is essential to improving the quality of life for children with life-threatening illnesses. The Paediatric Palliative Screening Scale (PaPaS) has been validated internationally, but it has not yet been evaluated in mainland China, where PPC infrastructure remains limited and fragmented. The aim of this study is to adapt the PaPaS into Chinese and evaluate its diagnostic performance in identifying PPC needs among children with acute lymphoblastic leukemia (ALL) during induction chemotherapy.

methodsThis retrospective diagnostic accuracy study included children aged 0–18 years newly diagnosed with ALL who initiated induction therapy under the CCCG-ALL-2020 protocol at a tertiary pediatric hospital in China (August 2020–August 2023). The Chinese version of the PaPaS (C-PaPaS) was developed through forward–backward translation and expert review. Scores were retrospectively assigned using electronic medical records. Receiver operating characteristic (ROC) analysis was used to assess diagnostic performance and identify the optimal cutoff.

resultsAmong 153 patients, 28.1% received PPC interventions. Median C-PaPaS scores were significantly higher in the PPC group (23 [IQR 17–25]) than in the non-PPC group (15 [14–19]; P < 0.001). At a cutoff score of > 22, the C-PaPaS demonstrated high sensitivity (93.0%) and moderate specificity (41.8%), with an area under the ROC curve of 0.79 (95% CI: 0.71–0.87).

conclusionsThe C-PaPaS demonstrated strong sensitivity and moderate discriminative accuracy in identifying PPC needs among children with ALL. It may serve as a useful triage tool to support early palliative integration, especially in settings with limited PPC infrastructure.

Indexed as

Mass ScreeningNeeds AssessmentPalliative CarePrecursor Cell Lymphoblastic Leukemia-LymphomaAdolescentChildChild, PreschoolChinaFemaleHumansInfantInfant, NewbornMalePediatricsPsychometricsRetrospective StudiesDiagnostic accuracyPediatric palliative carePediatric palliative screening scaleSensitivity and specificity

Identifiers

PMID41992173
PMCPMC13224670

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