Evidence map›Paper›PMID 41992090›Full record

ArticleBMC microbiology2026

Comparative pangenomics of Pasteurella multocida uncovers adhesins specific to capsular serogroup B strains associated with bovine host tropism.

Venugopal Nandish, Pillenahalli Sadashivappa Pooja, Anand Shirisha, Suresh Bindu, Mandrira Ramakrishna Namrutha, V G Shanmuga Priya, Mohammed Mudassar Chanda, Sathish Bhadravati Shivachandra

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Venugopal NandishICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Post Box No. 6450, Yelahanka, Bengaluru, Karnataka, 560 119, India.
Pillenahalli Sadashivappa PoojaICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Post Box No. 6450, Yelahanka, Bengaluru, Karnataka, 560 119, India.
Anand ShirishaICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Post Box No. 6450, Yelahanka, Bengaluru, Karnataka, 560 119, India.
Suresh BinduICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Post Box No. 6450, Yelahanka, Bengaluru, Karnataka, 560 119, India.
Mandrira Ramakrishna NamruthaICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Post Box No. 6450, Yelahanka, Bengaluru, Karnataka, 560 119, India.
V G Shanmuga PriyaDepartment of Life Sciences, Garden City University, Bengaluru, Karnataka, 560 049, India.
Mohammed Mudassar ChandaICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Post Box No. 6450, Yelahanka, Bengaluru, Karnataka, 560 119, India.
Sathish Bhadravati ShivachandraICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Post Box No. 6450, Yelahanka, Bengaluru, Karnataka, 560 119, India. sb.shivachandra@icar.org.in.

Funding

Indian Council of Agricultural Research IXX20081
6 · The paper itself

Abstract

Haemorrhagic septicaemia (HS), an acute and highly fatal disease of bovines in tropical countries of Africa and Asia, including India, is primarily caused by Pasteurella multocida serogroup B:2 strains. Although P. multocida strains are ubiquitous and known to infect a wide range of host species with varied clinical manifestations hitherto, the molecular basis of host tropism remains unknown. In this study, we present an integrated genomic, structural, and molecular dynamics framework to investigate how P. multocida serogroup B strains selectively adhere to bovine tissues. Comparative pangenomic analysis identified 115 genes significantly enriched in serogroup B strains, among which five lineage-specific putative adhesins were predicted through a multi-layer computational pipeline. In silico adhesin-fibronectin docking and interface energetics analyses identified preferential binding of these five adhesins to bovine fibronectin FnIII 9–10 domains, with markedly weaker interactions observed for non-bovine (caprine, pig, chicken and rabbit) homologues. Molecular dynamics simulations further revealed exceptional structural stability and favourable binding energetics for three adhesins (PACFBAAN_02021, PACFBAAN_00422 and PACFBAAN_00429), whereas two adhesins (PACFBAAN_01225 and PACFBAAN_01232) exhibited substantially lower adhesive performance. Together, these adhesins represent a potential molecular signature of bovine host tropism and warrant experimental validation for diagnostics, anti-adhesion therapeutics, and subunit vaccine development.

Indexed as

Adhesins, BacterialPasteurella InfectionsPasteurella multocidaAnimalsBacterial AdhesionBacterial CapsulesCattleCattle DiseasesFibronectinsGenomicsHemorrhagic SepticemiaHost TropismMolecular Docking SimulationMolecular Dynamics SimulationProtein BindingSerogroupAdhesins, BacterialFibronectinsAdhesinsFibronectin FnIII 9–10 domainsHaemorrhagic septicaemiaMolecular dynamics simulationsPasteurella multocida

Identifiers

PMID41992090
PMCPMC13214154

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.