ArticlePest management science2026
A perillaldehyde-derived virucide targets phytoviral coat protein at Ser207 to impede intercellular spread.
Article in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPlant viruses rely on long-distance transport to establish systemic infection within hosts, and cell-to-cell movement is often a prerequisite for vascular entry and subsequent systemic spread. Therefore, interference with virus movement represents an attractive antiviral strategy. Here, we report a series of perillaldehyde-derived compounds bearing an α-aminophosphonate moiety, evaluate their anti-phytoviral activities, and elucidate the mechanism of a representative lead.
resultsA total of 38 target derivatives were designed and synthesized by introducing an aminophosphonate pharmacophore onto the perillaldehyde scaffold. Using the half-leaf lesion assay, compound Y14 was identified as a potent inhibitor against Potato virus Y (PVY), exhibiting an inactivation half-maximal effective concentration (EC
conclusionThis study identifies compound Y14 as an antiviral lead that targets PVY CP and functionally compromises viral intercellular spread, thereby suppressing systemic infection. These findings provide a mechanistically distinctive chemical for PVY management. © 2026 Society of Chemical Industry.
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