Evidence map›Paper›PMID 41992064›Full record

ArticleNature nanotechnology2026

Enhancing antitumour nanovaccine efficacy via integrated cholesterol modulation in situ.

Zihan Deng, Lisen Lu, Tianbing Xu, Zhitong Zhao, Yuanyuan Geng, Li Liu, Muyang Yang, Yongfa Zheng, Yao Sun, Jonathan F Lovell and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature nanotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Nanomaterials-Based Immunotherapy for Atherosclerosis.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zihan Deng *College of Biomedicine and Health and College of Life Science and Technology, Huazhong Agricultural University, Wuhan, People's Republic of China.ORCID http://orcid.org/0009-0008-7100-9842
Lisen Lu *NHC Key Laboratory of Tropical Disease Control, School of Life Sciences and Medical Technology, Hainan Medical University, Haikou, People's Republic of China.
Tianbing Xu *College of Biomedicine and Health and College of Life Science and Technology, Huazhong Agricultural University, Wuhan, People's Republic of China.ORCID http://orcid.org/0000-0002-3568-5332
Zhitong ZhaoKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, People's Republic of China.
Yuanyuan GengCollege of Biomedicine and Health and College of Life Science and Technology, Huazhong Agricultural University, Wuhan, People's Republic of China.
Li LiuCollege of Biomedicine and Health and College of Life Science and Technology, Huazhong Agricultural University, Wuhan, People's Republic of China.
Muyang YangNHC Key Laboratory of Tropical Disease Control, School of Life Sciences and Medical Technology, Hainan Medical University, Haikou, People's Republic of China.
Yongfa ZhengDepartment of Oncology, Renmin Hospital of Wuhan University, Wuchang District, Wuhan, People's Republic of China.
Yao SunCollege of Biomedicine and Health and College of Life Science and Technology, Huazhong Agricultural University, Wuhan, People's Republic of China. sunyaogbasp@mail.hzau.edu.cn.ORCID http://orcid.org/0000-0002-6519-7436
Jonathan F LovellDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY, USA. jflovell@buffalo.edu.ORCID http://orcid.org/0000-0002-9052-884X
Xuesi ChenKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, People's Republic of China.ORCID http://orcid.org/0000-0003-3542-9256
Jianxun DingKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, People's Republic of China. jxding@ciac.ac.cn.ORCID http://orcid.org/0000-0002-5232-8863
Honglin JinCollege of Biomedicine and Health and College of Life Science and Technology, Huazhong Agricultural University, Wuhan, People's Republic of China. jin@hust.edu.cn.ORCID http://orcid.org/0000-0002-4398-9539

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82473363
6 · The paper itself

Abstract

Antigen presentation is a central component of host immune responses to cancer vaccinations; however, antigen-presenting cells often fail to promote sufficient proliferation of specific T cells, thereby restricting their efficacy. This study shows that manipulating the cholesterol levels in dendritic cell (DC) membranes could enhance the antigen-presenting capability. On the basis of this finding, we developed a membrane-cholesterol-depleting nanovaccine designed to deliver antigens to DCs and simultaneously reduce the membrane cholesterol. The direct deprivation of membrane cholesterol enhanced the contact frequency between DCs and T cells and reshaped the tumour immune microenvironment to inhibit tumourigenesis and progression in multiple tumour models. Mechanistically, the designed nanovaccines promoted immune synapse formation with CD8

Indexed as

Cancer VaccinesCholesterolNanovaccinesAnimalsAntigen PresentationCD8-Positive T-LymphocytesDendritic CellsHumansLymphocyte ActivationMiceMice, Inbred C57BLTumor MicroenvironmentCancer VaccinesCholesterolNanovaccines

Identifiers

PMID41992064

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.