Evidence map›Paper›PMID 41992056›Full record

ReviewCancer medicine2026

Immunotherapy in Thyroid Cancer: Current Strategies and Challenges.

Qian Zhang, Fan Wang, Wenbin Ma, Nan Liu, Yihan Lu, Ping Zhang

Abstract readReview
In one paragraph

Review in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qian ZhangSecond Hospital of Dalian Medical University, Dalian, China.
Fan WangDepartment of Endocrinology and Metabolism, Second Hospital of Dalian Medical University, Dalian, China.
Wenbin MaDepartment of Endocrinology and Metabolism, Second Hospital of Dalian Medical University, Dalian, China.
Nan LiuDepartment of Endocrinology and Metabolism, Second Hospital of Dalian Medical University, Dalian, China.
Yihan LuDepartment of Endocrinology and Metabolism, Second Hospital of Dalian Medical University, Dalian, China.ORCID https://orcid.org/0009-0000-6702-7927
Ping ZhangDepartment of Endocrinology and Metabolism, Second Hospital of Dalian Medical University, Dalian, China.

Funding

Dalian Science and Technology Bureau 2023RQ013National Natural Science Foundation of China 82200878
6 · The paper itself

Abstract

Thyroid cancer is the most common endocrine malignancy, with an increasing global incidence. Despite advances in conventional treatments, such as surgery, radioactive iodine therapy, and TSH suppression, the management of advanced and aggressive forms, such as anaplastic thyroid carcinoma and refractory differentiated thyroid carcinoma, remains a challenge. Immunotherapy has emerged as a promising approach, with immune checkpoint inhibitors (ICIs) like PD-1/PD-L1 and B7-H3 showing potential in enhancing antitumor immunity. Additionally, immune cells such as CD4+, CD8+, and M2 macrophages are key players in the tumor microenvironment, influencing treatment responses and serving as prognostic biomarkers. Combining ICIs with targeted therapies or adoptive cell therapies is being explored to overcome resistance and improve efficacy. However, challenges such as tumor heterogeneity and immune evasion mechanisms persist.

Indexed as

Immune Checkpoint InhibitorsImmunotherapyThyroid NeoplasmsAnimalsHumansTumor MicroenvironmentImmune Checkpoint Inhibitorsadoptive cell therapycombination therapyimmune checkpointsimmunotherapyPD‐1PD‐L1personalized treatmenttargeted therapythyroid cancertumor microenvironment

Identifiers

PMID41992056
PMCPMC13086570

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.