Evidence map›Paper›PMID 41992046›Full record

ArticleScientific reports2026

Operational checks for real-time urinary biomarker measurements for assessment of the quality of deceased donor kidneys.

Mitali Barik, Serena DSouza, Wassim Obeid, David Hu, Sophia Xu, Mona Doshi, Sumit Mohan, Elyssa Gansner, Gary Marklin, Nick Olden and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mitali Barik *Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Serena DSouza *Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Wassim ObeidDivision of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
David HuDivision of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sophia XuDivision of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mona DoshiDepartment of Medicine, University of Michigan, Ann Arbor, MI, USA.
Sumit MohanDivision of Nephrology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Elyssa GansnerMid-America Transplant, St Louis, MO, USA.
Gary MarklinMid-America Transplant, St Louis, MO, USA.
Nick OldenGift of Life Michigan, Ann Arbor, MI, USA.
Wrenn WoodardGift of Life Michigan, Ann Arbor, MI, USA.
Walter HerczykGift of Life Michigan, Ann Arbor, MI, USA.
Heather Thiessen PhilbrookDivision of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Chirag R ParikhDivision of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. chirag.parikh@jhmi.edu.

Funding

NIH HHS R01DK-93770
6 · The paper itself

Abstract

Lateral flow devices (LFDs) were integrated into the clinical organ procurement workflow of two organ procurement organizations (OPOs) to obtain measurements of urinary biomarkers uromodulin (UMOD), osteopontin (OPN), and chitinase-3-like protein 1 (YKL-40) in deceased donors. We report on the feasibility of expanding the procurement workflow with this point-of-care testing, as well as methods of monitoring study performance and sample integrity through quality checks (QCs). Data QCs were implemented at OPO sample collection, transport/storage, processing, sample shipment back to the data coordinating center, and data transcription. From April 2022 to April 2025, 62 laboratory staff at two OPOs measured repair biomarkers of 958 samples from 879 unique donors. 4% of samples (n = 35) were excluded due to sample QCs, such as being left unfrozen beyond acceptable protocol ranges. These exclusions resulted in 923 samples from 851 unique donors [720 donors after brain death (DBD), 131 donors after circulatory death (DCD)]. Median processing time of LFD biomarker measurements across OPOs was 46 min (IQR: 40–55) and 5.1% cases required LFD remeasurement due to invalid readings. Developed QCs were used to identify samples suitable for research purposes and have been summarized into a checklist for use in multidisciplinary sciences.

Indexed as

BiomarkersKidneyKidney TransplantationTissue and Organ ProcurementTissue DonorsBrain DeathHumansQuality ControlUromodulinBiomarkersUromodulinDeceased donorsDonorsLateral flow devicesOrgan procurement organizationQuality checksSample integrityTransplantationUrine

Identifiers

PMID41992046
PMCPMC13247077

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.