Evidence map›Paper›PMID 41992045›Full record

ArticleCommunications chemistry2026

Diversification of the 10th core atom of 9-cyanopyronins expands the resonance Raman vibrational palette.

Shun-Suke Kanai, Hiroyoshi Fujioka, Minoru Kawatani, Spencer John Spratt, Shun-Suke Fukuta, Zhihao Zhan, Yang Ma, Kazuhiro Kuruma, Daisuke Asanuma, Yuichi Asada and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shun-Suke KanaiDepartment of Life Science and Technology, Institute of Science Tokyo, Yokohama, Kanagawa, Japan.ORCID http://orcid.org/0009-0009-6449-2589
Hiroyoshi FujiokaLaboratory for Chemistry and Life Science, Institute of Integrated Research, Institute of Science Tokyo, Yokohama, Kanagawa, Japan. fujioka.h.cdc5@m.isct.ac.jp.ORCID http://orcid.org/0000-0003-1904-0566
Minoru KawataniLaboratory for Chemistry and Life Science, Institute of Integrated Research, Institute of Science Tokyo, Yokohama, Kanagawa, Japan.
Spencer John SprattResearch Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-5429-8856
Shun-Suke FukutaResearch Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
Zhihao ZhanResearch Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
Yang MaDepartment of Electrical Engineering and Information Systems, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Kazuhiro KurumaResearch Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
Daisuke AsanumaLaboratory for Chemistry and Life Science, Institute of Integrated Research, Institute of Science Tokyo, Yokohama, Kanagawa, Japan.
Yuichi AsadaDepartment of Chemistry, Graduate School of Science, and Integrated Research Consortium on Chemical Sciences (IRCCS), Nagoya University, Nagoya, Chikusa, Japan.
Masayasu TakiInstitute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan.
Shigehiro YamaguchiDepartment of Chemistry, Graduate School of Science, and Integrated Research Consortium on Chemical Sciences (IRCCS), Nagoya University, Nagoya, Chikusa, Japan.
Yasuyuki OzekiResearch Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-9004-0799
Mako KamiyaLaboratory for Chemistry and Life Science, Institute of Integrated Research, Institute of Science Tokyo, Yokohama, Kanagawa, Japan. kamiya.m.f150@m.isct.ac.jp.ORCID http://orcid.org/0000-0002-5592-1849

Funding

Japan Agency for Medical Research and Development (AMED) JP23gm1910004, 24zf0127012MEXT | Japan Science and Technology Agency (JST) JPMJCR2331MEXT | Japan Science and Technology Agency (JST) JPMJFR221M, JPMJCR2331MEXT | Japan Society for the Promotion of Science (JSPS) JP23K19240MEXT | Japan Society for the Promotion of Science (JSPS) JP25K01892, JP24H00050
6 · The paper itself

Abstract

9-Cyanopyronin derivatives have been used as resonance Raman probes for highly sensitive and multiplexed vibrational biological imaging. Here, we synthesized a series of fourteen 9-cyanopyronin derivatives in which the 10th core atom is substituted with various group 13, 14, 15 or 16 elements, and systematically evaluated their properties using electronic pre-resonance stimulated Raman scattering (EPR-SRS) microscopy. Substitution at the 10th position modulates not only the vibrational frequency of the nitrile (C ≡ N) group in the silent region, but also the conjugated double-bond stretching frequency (C = C) in the fingerprint region, and additionally alters the subcellular localization of the probes. By employing different combinations of probes, we were able to utilize the distinct patterns of C ≡ N or C = C bond vibrations together with the different subcellular localizations of the probes to achieve live-cell three-color imaging. These 9-cyanopyronin derivatives greatly expand the vibrational palette available for multiplexed SRS imaging.

Identifiers

PMID41992045
PMCPMC13260890

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.