ArticleEye (London, England)2026
Diabetes and uveitis. A large cohort evaluation of the association between glycaemic control and incident undifferentiated anterior uveitis. (The DULCE Study).
Article in Eye (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
objectivesTo determine whether the risk of incident, undifferentiated, anterior uveitis increases with worsening glycaemic control. SUBJECTS/
methodsThis retrospective, multicentre cohort study analysed 12,192,033 adults (>= 18 years) from the TriNetX database (2010-2023). Individuals with pre-existing uveitis or systemic inflammatory diseases were excluded. The primary outcome was the incidence of undifferentiated anterior uveitis. HbA1c was modelled both categorically (non-diabetic, well-controlled diabetes [<8.0%], poorly controlled diabetes [>= 8.0%]) and continuously. Cox proportional hazards regression estimated adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs); logistic regression modelled the continuous association.
resultsIncreasing HbA1c levels were strongly associated with incident uveitis (P < 0.001). Compared with non-diabetic controls, risk was elevated among patients with well-controlled diabetes (aHR 3.25; 95% CI 3.16-3.34) and further increased with poor control (aHR 4.07; 95% CI 3.95-4.19). For each 1% rise in HbA1c, the odds of developing uveitis increased by 10% (adjusted OR 1.10; 95% CI 1.10-1.11). Predicted probabilities rose non-linearly, reaching 1.11% at HbA1c 18%.
conclusionsThe risk of undifferentiated anterior uveitis increases with increasing HbA1c values.
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