Evidence map›Paper›PMID 41991947›Full record

ArticleNature communications2026

Spinal cord structural and functional architecture and its shared organization with the brain across the adult lifespan.

Caroline Landelle, Nawal Kinany, Samuelle St-Onge, Ovidiu Lungu, Dimitri Van De Ville, Bratislav Misic, Véronique Marchand-Pauvert, Benjamin De Leener, Julien Doyon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Caroline LandelleMcConnell Brain Imaging Centre, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada. caroline.landelle@mcgill.ca.ORCID http://orcid.org/0000-0001-5245-2824
Nawal KinanyDepartment of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland.
Samuelle St-OngeNeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada.
Ovidiu LunguMcConnell Brain Imaging Centre, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
Dimitri Van De VilleDepartment of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland.ORCID http://orcid.org/0000-0002-2879-3861
Bratislav MisicMcConnell Brain Imaging Centre, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0003-0307-2862
Véronique Marchand-PauvertSorbonne Université, Inserm, CNRS, Laboratoire d'Imagerie Biomédicale, LIB, Paris, France.ORCID http://orcid.org/0000-0002-0226-7169
Benjamin De LeenerNeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-1378-2756
Julien DoyonMcConnell Brain Imaging Centre, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-3788-4271

Funding

Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada (NSERC Canadian Network for Research and Innovation in Machining Technology) 248074Fondation Brain Canada (Fondation Neuro Canada) 255934Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) 13556932
6 · The paper itself

Abstract

The spinal cord connects the brain to peripheral systems. Yet its integration with cerebral networks remains a key neuroscience question. Capturing structural and functional central nervous system (CNS) changes throughout the lifespan is essential for characterizing healthy and pathological aging. Leveraging a unique multimodal dataset combining spinal and cerebrospinal imaging, we jointly mapped the spinal cord structural and functional architecture across adulthood. Our results revealed age-related changes across these modalities and identified organizational principles shared with the brain. These changes were most pronounced in the somatosensory pathway, with microstructural decline coupled to shifts in functional connectivity and local spontaneous activity as aging progresses. Extending analyses to the brain uncovered convergent CNS-wide aging mechanisms, including gray matter loss, decreased functional segregation, and increased spontaneous activity, highlighting shared neural aging trajectories. Together, our findings provide a systems-level view of the age-related alteration in the CNS, offering a foundation for future studies investigating potential imaging markers of sensorimotor dysfunction.

Indexed as

AgingBrainLongevitySpinal CordAnimalsFemaleGray MatterHumansMagnetic Resonance Imaging

Identifiers

PMID41991947
PMCPMC13265777

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.