ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2026
Cognition and psychomotor vigilance in treated sleep apnea patients with and without daytime sleepiness: the MAGNETO study.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Reply to "Occupational sleep restriction: a missing piece in residual EDS of PAP-adherent OSA?"Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Occupational sleep restriction: a missing piece in residual EDS of PAP-adherent OSA?Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Reply to "Validating the psychomotor vigilance task cutoff for residual excessive daytime sleepiness in treated obstructive sleep apnea".Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Validating the psychomotor vigilance task cutoff for residual excessive daytime sleepiness in treated obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
STUDY
objectivesResidual excessive daytime sleepiness (EDS) persists in some patients with obstructive sleep apnea (OSA) despite adequate positive airway pressure (PAP) therapy and is linked to cognitive deficits. This study examined whether residual EDS in PAP-adherent OSA is associated with poorer cognition.
methodsA cross-sectional single site study (N = 65), examining PAP-adherent (mean use ≥ 6 h/night; device reported normalized AHI < 5 per hour) patients with OSA (mean age (SD) = 61 (9.2); 34% female; 72% Hispanic; 6% Black; mean diagnostic AHI = 38.05 (28.4). Objective sleepiness was measured via the Psychomotor Vigilance Task (PVT); > 5 lapses ≥ 500 ms defined PVT derived EDS (N = 30). Cognitive function assessed via NeuroTrax® battery accounting for age and education. General linear models adjusted for sex, time since diagnosis and self-reported sleep duration were used to test associations in this exploratory, hypothesis generating analysis.
resultsGreater residual EDS was associated with worse performance in global cognition (β = -4.09, p < .001), memory (β = -3.97, p = .001), executive functioning (β = -3.91, p = .004), attention (β = -2.68, p = .036), and processing speed (β = -4.89, p = .012). In categorical analyses, those with EDS performed approximately .43-.58 of a NeuroTrax® SD worse in global cognition and memory, a magnitude roughly comparable to 1-2 points on the MoCA or MMSE.
conclusionsResidual EDS was associated with poorer cognitive performance. These findings suggest residual EDS represents a cognitive risk phenotype in OSA, independent of PAP adherence. PVT provides a brief, objective tool to detect cognitive deficits and may serve as a valuable measure in OSA related brain health research. Current Knowledge/Study Rationale In obstructive sleep apnea (OSA), residual excessive daytime sleepiness (EDS) can persist despite regular adherence to positive airway pressure (PAP) therapy. EDS is associated with cognitive decline and dementia risk, yet few studies have evaluated objective sleepiness and cognitive outcomes in this population. Study Impact This study shows that residual EDS, objectively measured by the Psychomotor Vigilance Task (PVT), is associated with worse cognition in PAP-adherent people with OSA. These findings highlight a distinct cognitive risk phenotype in treated OSA and support the PVT as a practical tool for detecting cognitive deficits in clinical and research settings.
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