SynthesisInfection2026
Incidence of infectious endophthalmitis after keratoplasty surgery: an updated systematic review and meta-analysis.
Synthesis in Infection, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Global trends and knowledge structure of tetanus research from 2005 to 2025: A bibliometric analysis based on web of science Core Collection and Scopus.One health (Amsterdam, Netherlands) · 2026Article
- Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionInfectious endophthalmitis is a rare but vision-threatening complication following keratoplasty. With the evolution of corneal transplantation techniques toward endothelial keratoplasty (EK) and anterior lamellar keratoplasty (ALK), contemporary pooled incidence estimates stratified by surgical technique and geographic region are required to inform perioperative prevention strategies and postoperative surveillance. This study aimed to provide an updated systematic review and single-arm meta-analysis evaluating the incidence and risk factors of infectious endophthalmitis after keratoplasty.
methodsThis systematic review and meta-analysis was conducted according to PRISMA guidelines. Five databases (PubMed, Scopus, Web of Science, ScienceDirect, and Cochrane Library) were searched from inception to December 31, 2025. Observational studies reporting incidence of infectious endophthalmitis after keratoplasty were included. A random-effects single-arm meta-analysis of proportions with logit transformation was performed. Subgroup analyses were conducted by keratoplasty type, geographic region, study period, and follow-up duration. Heterogeneity was assessed using the I
resultsTwenty-one studies comprising multiple keratoplasty procedures were included. The pooled incidence of infectious endophthalmitis after keratoplasty was 0.40% (95% CI 0.30-0.50), with a prediction interval of 0.08-1.95%, indicating substantial between-study variability. Significant heterogeneity was observed (I
conclusionPost-keratoplasty infectious endophthalmitis remains uncommon but clinically consequential. Penetrating keratoplasty showed a higher pooled incidence than lamellar techniques in this synthesis, and meaningful geographic variation persists. These findings indicate lower pooled incidence estimates with lamellar techniques in this synthesis and highlight the importance of rigorous perioperative infection-prevention strategies.
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