Evidence map›Paper›PMID 41991728›Full record

ArticleArchives of toxicology2026

Therapeutically relevant rimonabant exposure drives epigenetic remodeling in neuronal cells and rat brain tissue.

Sandra I Marques, Matilde Barreiras de Moura, Federica Panza, Catarina Pereira-Teixeira, Vladimir Stevanović, Aleksandra Kovačević, Miroslav M Savić, Helena Carmo, Susana I Sá, Félix Carvalho and 1 more

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In one paragraph

Article in Archives of toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sandra I MarquesUCIBIO - Applied Molecular Biosciences Unit, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, 4050-313, Porto, Portugal.
Matilde Barreiras de MouraUCIBIO - Applied Molecular Biosciences Unit, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, 4050-313, Porto, Portugal.
Federica PanzaUCIBIO - Applied Molecular Biosciences Unit, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, 4050-313, Porto, Portugal.
Catarina Pereira-TeixeiraUCIBIO - Applied Molecular Biosciences Unit, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, 4050-313, Porto, Portugal.
Vladimir StevanovićDepartment of Pharmacology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
Aleksandra KovačevićDepartment of Pharmacology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
Miroslav M SavićDepartment of Pharmacology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
Helena CarmoUCIBIO - Applied Molecular Biosciences Unit, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, 4050-313, Porto, Portugal.
Susana I SáRISE-HEALTH, Faculty of Medicine, University of Porto, Porto, Portugal.
Félix CarvalhoUCIBIO - Applied Molecular Biosciences Unit, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, 4050-313, Porto, Portugal. felixdc@ff.up.pt.
João Pedro SilvaUCIBIO - Applied Molecular Biosciences Unit, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, 4050-313, Porto, Portugal. jpmsilva@ff.up.pt.ORCID 0000-0002-5656-0897

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rimonabant (SR141716A), an inverse agonist of the cannabinoid receptor type 1 (CB

Indexed as

BrainEpigenesis, GeneticNeuronsRimonabantAcetylationAnimalsCell Line, TumorDNA MethylationDose-Response Relationship, DrugHistone DeacetylasesHistonesHumansMaleRatsRats, Sprague-DawleyReceptor, Cannabinoid, CB1Histone DeacetylasesHistonesReceptor, Cannabinoid, CB1RimonabantDNA methylationHistone acetylationHistone methylationPsychiatric and psychological adverse eventsSR141716A

Identifiers

PMID41991728
PMCPMC13309441

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.