Evidence map›Paper›PMID 41991696›Full record

ArticleCell and tissue research2026

An Lmx1a/b allelic series reveals the role of Lmx1 genes in cochlear nuclei development.

Igor Y Iskusnykh, Bernd Fritzsch, Ebenezer N Yamoah, Ekaterina Y Steshina, Victor V Chizhikov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell and tissue research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Igor Y IskusnykhDepartment of Anatomy and Neurobiology, The University of Tennessee Health Science Center, Memphis, TN, 38163, USA. iiskusny@uthsc.edu.
Bernd FritzschDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Ebenezer N YamoahDepartment of Translational Neuroscience, College of Medicine-Phoenix, Phoenix, AZ, 85004, USA.
Ekaterina Y SteshinaDepartment of Anatomy and Neurobiology, The University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Victor V ChizhikovDepartment of Anatomy and Neurobiology, The University of Tennessee Health Science Center, Memphis, TN, 38163, USA. vchizhik@uthsc.edu.

Funding

Structural Analyses CoreP01AG051443 · NIA · UNIVERSITY OF NEVADA RENO · PI YAMOAH, EBENEZER N · 2016 to 2025
$15.5M
Inner ear ion channels in healthy and diseased conditionsR01DC016099 · NIDCD · UNIVERSITY OF NEVADA RENO · PI EBENEZER N YAMOAH · 2017 to 2026
$4.7M
Mechanisms of Growth Factor Responsiveness in the Aging Auditory SystemR01AG060504 · NIA · UNIVERSITY OF NEVADA RENO · PI FRITZSCH, BERND, YAMOAH, EBENEZER N · 2018 to 2022
$2.5M
Nf2-dependent regulation of neuronal scaling in the developing cerebellumR01NS127973 · NINDS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Viktor Chizhikov · 2022 to 2026
$2.1M
Cochlear neuron functions and diseasesR01DC022866 · NIDCD · UNIVERSITY OF ARIZONA · PI EBENEZER N YAMOAH · 2025 to 2026
$1.3M
NIA NIH HHS P01 AG051443NIA NIH HHS R01 AG060504NIDCD NIH HHS R01 DC016099NIDCD NIH HHS R01 DC022866NIH HHS AG051443NIH HHS NS127973NINDS NIH HHS R01 NS127973
6 · The paper itself

Abstract

Lmx1a/b paralogous genes, which arose from the invertebrate Lmx1b-like gene, are critical for hearing in multiple vertebrate species, and mutations in these genes cause hearing deficits in humans. While the unique and redundant functions of Lmx1a/b in the inner ear are well established, their contribution to the development of the cochlear nuclei, which process and relay auditory information to the brain, is poorly understood. Since cochlear nuclei maturate postnatally, here we analyzed Lmx1a

Indexed as

AllelesCochlear NucleusLIM-Homeodomain ProteinsTranscription FactorsAnimalsGene Expression Regulation, DevelopmentalMiceLIM homeobox transcription factor 1 betaLIM-Homeodomain ProteinsLmx1a protein, mouseTranscription FactorsBmp signalingCentral auditory projectionsCochlear nucleiInner earLmx1aLmx1bRhombic lipRoof plate

Identifiers

PMID41991696
PMCPMC13086785

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.