ArticleScientific reports2026
Aqueous and methanol extracts of Paullinia pinnata improve MSUc uptake in macrophages and in vitro antioxidant effects.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Extracts of Paullinia pinnata have demonstrated therapeutic effects in monosodium urate (MSU)-induced gout in rats, notably by reducing inflammation and hyperalgesia, as well as enhancing antioxidant activity in vivo. However, their in vitro antioxidant potential and their effects on MSU-stimulated macrophages remain insufficiently explored. This study aims to investigate the in vitro antioxidant properties of P. pinnata, with a particular focus on MSU uptake in stimulated macrophages. The in vitro antioxidant activities of aqueous (AEPP) and methanolic (MEPP) extracts of P. pinnata leaves were evaluated using a range of assays, including DPPH radical scavenging, hydroxyl radical scavenging, nitric oxide inhibition, reducing power, hydrogen peroxide-induced hemolysis of rat red blood cells, hydrogen peroxide-induced brain lipid peroxidation, as well as the determination of total flavonoid and polyphenol content. Peritoneal macrophages isolated from rats were pretreated with AEPP and MEPP (10, 30, and 100 µg/mL) for 1 h, followed by stimulation with MSU (10 mg/dL) for 24 h. Subsequently, cell viability, lactate dehydrogenase (LDH) release, nitric oxide (NO) production, MSU uptake, superoxide dismutase (SOD) activity, and reduced glutathione (GSH) levels were measured in the culture medium. AEPP and MEPP significantly inhibited DPPH radicals, with IC
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