Evidence map›Paper›PMID 41991673›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Temporal trends in outcomes for infants with neonatal opioid withdrawal managed with the Finnegan scoring tool: Insights from the INFORM NOW Study.

Lori A Devlin, Walter K Kraft, Denise C Babineau, Evan Rhodes, Abhik Das, Margaret Crawford, Stephanie Merhar, Sucheta Telang, Lawrence Leeman, Gregory M Sokol and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lori A Devlin *Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY, USA. lori.devlinphinney@louisville.edu.ORCID http://orcid.org/0000-0003-3826-4733
Walter K Kraft *Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-5074-0141
Denise C BabineauData Analytics and Digital Solutions, RTI International, Research Triangle Park, NC, USA.ORCID http://orcid.org/0000-0002-9776-9080
Evan RhodesData Analytics and Digital Solutions, RTI International, Research Triangle Park, NC, USA.
Abhik DasData Analytics and Digital Solutions, RTI International, Research Triangle Park, NC, USA.ORCID http://orcid.org/0000-0003-2722-0479
Margaret CrawfordData Analytics and Digital Solutions, RTI International, Research Triangle Park, NC, USA.
Stephanie MerharDepartment of Pediatrics, University of Cincinnati College of Medicine and Perinatal Institute, Division of Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0002-3331-4220
Sucheta TelangDepartment of Pediatrics, University of Louisville School of Medicine, Louisville, KY, USA.ORCID http://orcid.org/0000-0002-7180-0350
Lawrence LeemanDepartment of Family and Community Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA.
Gregory M SokolDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0002-2917-1423
Namasivayam AmbalavananDivision of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0003-0731-9092
Sara B DeMauroDivision of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-1647-4000
Richard W HallDepartment of Pediatrics/Neonatology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.ORCID http://orcid.org/0000-0002-3264-3217
Scott A LorchDivision of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
HEAL Evaluation of Limited Pharmacotherapies for Neonatal Opioid Withdrawal Syndrome (HELP for NOWS) Consortium

Funding

Data Coordinating Center (DCC) for the Neonatal Opioid Withdrawal Syndrome Pharmacological Treatments Comparative Effectiveness Trial (NOWS PhaCET)U24HD107621 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI Abhik Das · 2021 to 2026
$25.6M
Neonatal Treatment TrialUG1HD107631 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI DEMAURO, SARA BONAMO, LORCH, SCOTT A · 2021 to 2025
$1.3M
HEAL initiative: Neonatal Opioid Withdrawal Syndrome Pharmacological Treatments Comparative Effectiveness Trial: Cincinnati siteUG1HD107616 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI MERHAR, STEPHANIE L · 2021 to 2025
$1.2M
HEAL Initiative: Neonatal Opioid Withdrawal Syndrome Pharmacological Treatments Comparative Effectiveness Trial Clinical SiteUG1HD107650 · NICHD · UNIV OF ARKANSAS FOR MED SCIS · PI HALL, RICHARD WHITTINGTON · 2021 to 2025
$1.1M
Neonatal Opioid Withdrawal Syndrome (NOWS) in Kentucky: Improving Outcomes for InfantsUG1HD107649 · NICHD · UNIVERSITY OF LOUISVILLE · PI DEVLIN-PHINNEY, LORI ANN, TELANG, SUCHETA · 2021 to 2025
$1.1M
Incorporating nonpharmacologic approaches into a comparative effectiveness pharmacologic trial for neonates with neonatal opioid withdrawal syndrome (NOWS)UG1HD107653 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI SOKOL, GREGORY M. · 2021 to 2025
$1.1M
HEAL Initiative: Neonatal Opioid Withdrawal Syndrome Pharmacological Treatments Comparative Effectiveness Trial New Mexico SiteUG1HD107627 · NICHD · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI LEEMAN, LAWRENCE M · 2021 to 2025
$1.1M
UAB Clinical Site HEAL Neonatal Opioid Withdrawal Pharmacological TreatmentsUG1HD107580 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AMBALAVANAN, NAMASIVAYAM · 2021 to 2025
$1.1M
Thomas Jefferson University Hospital Clinical Site for HEAL NOWS Pharmacologic TrialUG1HD107628 · NICHD · THOMAS JEFFERSON UNIVERSITY · PI ADENIYI-JONES, SUSAN, KRAFT, WALTER K · 2021 to 2025
$770k
NICHD NIH HHS U24 HD107621NICHD NIH HHS UG1 HD107580NICHD NIH HHS UG1 HD107616NICHD NIH HHS UG1 HD107627NICHD NIH HHS UG1 HD107628NICHD NIH HHS UG1 HD107631NICHD NIH HHS UG1 HD107649NICHD NIH HHS UG1 HD107650NICHD NIH HHS UG1 HD107653
6 · The paper itself

Abstract

objectiveTo evaluate changes in hospital outcomes for infants with neonatal opioid withdrawal syndrome (NOWS) assessed by the Finnegan Tool before (10/1/2019 to 12/31/2019;pre-epoch) and after (7/1/2021 to 3/31/2022;post-epoch) publication of the 2020 AAP NOWS clinical report. STUDY

designThis subgroup analysis included infants with NOWS assessed with the Finnegan Tool and enrolled in the INFORM NOW study (pre- and post-epoch 183 and 267 infants respectively).

resultsNo differences were found between epochs in initiation or length of pharmacologic treatment(LOT), or length of stay(LOS). Outcomes were modified by opioid type: LOT was 20% shorter (aMR=0.80; 95%CI:[0.69,0.93]) and LOS was 16% shorter (aMR=0.84; 95%CI:[0.73,0.96]) for buprenorphine treated infants post- compared to pre-epoch, while LOT and LOS were longer in the post-epoch for those treated with methadone.

conclusionThere was no difference in outcomes before and after publication of the AAP report. However, the type of postnatal opioid did modify study results.

Identifiers

PMID41991673
PMCPMC13251352

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.