ArticleScientific reports2026
Cross-species metabolic characterization of eutylone and mechanism-based inhibition of CYP2D6 and CYP2B6 with drug interaction implications.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Eutylone is a methylenedioxy-substituted synthetic cathinone increasingly detected in toxicological case analyses and commonly encountered under polydrug use conditions. To support metabolism-informed surveillance and risk assessment of emerging stimulants, this study comprehensively characterized eutylone disposition and interaction liability using plasma protein binding, metabolic stability in liver microsomes and hepatocytes across four species, untargeted feature-based molecular networking-based metabolite profiling, CYP phenotyping, and reversible and time-dependent inhibition assays. Eutylone exhibited moderate plasma protein binding (f
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