Evidence map›Paper›PMID 41991608›Full record

ArticleNature microbiology2026

Structure of Crimean-Congo haemorrhagic fever virus RNA polymerase.

Dong Wang, Ge Yang, Bin Liu

Abstract read
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In one paragraph

Article in Nature microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dong Wang *Section of Transcription and Gene Regulation, The Hormel Institute, University of Minnesota, Austin, MN, USA.ORCID http://orcid.org/0009-0007-0760-8165
Ge Yang *Section of Transcription and Gene Regulation, The Hormel Institute, University of Minnesota, Austin, MN, USA.
Bin LiuSection of Transcription and Gene Regulation, The Hormel Institute, University of Minnesota, Austin, MN, USA. liu00794@umn.edu.ORCID http://orcid.org/0000-0002-6581-780X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crimean-Congo haemorrhagic fever virus (CCHFV) is a highly pathogenic member of the Nairoviridae and causes severe disease with high fatality rates. Currently, there are no approved antivirals for CCHFV, but resolving the structure of its RNA-dependent RNA polymerase, termed L protein, could help drug development. Here we report cryogenic electron microscopy structures of the CCHFV L protein in both apo and RNA-bound states at 2.62 Å and 2.53 Å, respectively. These structures define the molecular architecture of the PA-, PB1- and PB2-like domains within the polymerase core, elucidate the mechanism of promoter recognition and reveal RNA-induced conformational changes that stabilize catalytic elements. Together, these insights provide a structural framework for understanding nairovirus replication and enable structure-based development of polymerase inhibitors.

Indexed as

DNA-Directed RNA PolymerasesHemorrhagic Fever Virus, Crimean-CongoRNA-Dependent RNA PolymeraseViral ProteinsCryoelectron MicroscopyModels, MolecularProtein ConformationRNA, ViralDNA-Directed RNA PolymerasesRNA-Dependent RNA PolymeraseRNA, ViralViral Proteins

Identifiers

PMID41991608

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.